Synergistic immuno photothermal nanotherapy (SYMPHONY) to treat metastatic cancers and induce anti-cancer vaccine effect

Published

Conference Paper

© 2018 SPIE. Biocompatible gold nanostars (GNS) with tip-enhanced electromagnetic and optical properties have been developed and applied for multifunctional cancer diagnostics and therapy (theranostics). Their multiple sharp branches acting like "lightning rods" can convert safely and efficiently light into heat. As with other nanoparticles, GNS sizes can be controlled so that they passively accumulate in tumors due to the enhanced permeability and retention (EPR) effect of tumor vasculature. This feature improves tumor-targeting precision and permits the use of reduced laser energy required to destroy the targeted cancer cells. The ability to selectively heat tumor areas where GNS are located while keeping surrounding healthy tissues at significantly lower temperatures offers significant advantages over other thermal therapies. GNS-mediated photothermal therapy combined with checkpoint immunotherapy was shown to reverse tumor-mediated immunosuppression, leading to the treatment of not only primary tumors but also cancer metastasis as well as inducing effective long-lasting immunity, i.e. an anticancer 'vaccine' effect.

Full Text

Duke Authors

Cited Authors

  • Vo-Dinh, T; Inman, B; Maccarini, P; Palmer, G; Liu, Y

Published Date

  • January 1, 2018

Published In

Volume / Issue

  • 10484 /

International Standard Serial Number (ISSN)

  • 1605-7422

International Standard Book Number 13 (ISBN-13)

  • 9781510614536

Digital Object Identifier (DOI)

  • 10.1117/12.2300089

Citation Source

  • Scopus