HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect.
Published online
Journal Article
Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dying cells during radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell proliferation. This effect was due to binding of HMGB1with the member receptor for advanced glycation end-products (RAGE), which activated downstream ERK and p38 signaling pathway and promoted cell proliferation. Furthermore, higher HMGB1 expression in tumor tissue correlated with poor overall survival and higher HMGB1 concentration was detected in serum of patients who accepted radiotherapy. Collectively, the results from this study suggested that interaction between dead cells and surviving cells might influence the fate of tumor. HMGB1 could be a novel tumor promoter with therapeutic and prognostic relevance in cancers.
Full Text
Duke Authors
Cited Authors
- He, S; Cheng, J; Sun, L; Wang, Y; Wang, C; Liu, X; Zhang, Z; Zhao, M; Luo, Y; Tian, L; Li, C; Huang, Q
Published Date
- May 29, 2018
Published In
Volume / Issue
- 9 / 6
Start / End Page
- 648 -
PubMed ID
- 29844348
Pubmed Central ID
- 29844348
Electronic International Standard Serial Number (EISSN)
- 2041-4889
Digital Object Identifier (DOI)
- 10.1038/s41419-018-0626-6
Language
- eng
Conference Location
- England