HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect.

Published online

Journal Article

Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released by dying cells during radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition or genetic ablation of HMGB1 suppressed tumor cell proliferation. This effect was due to binding of HMGB1with the member receptor for advanced glycation end-products (RAGE), which activated downstream ERK and p38 signaling pathway and promoted cell proliferation. Furthermore, higher HMGB1 expression in tumor tissue correlated with poor overall survival and higher HMGB1 concentration was detected in serum of patients who accepted radiotherapy. Collectively, the results from this study suggested that interaction between dead cells and surviving cells might influence the fate of tumor. HMGB1 could be a novel tumor promoter with therapeutic and prognostic relevance in cancers.

Full Text

Duke Authors

Cited Authors

  • He, S; Cheng, J; Sun, L; Wang, Y; Wang, C; Liu, X; Zhang, Z; Zhao, M; Luo, Y; Tian, L; Li, C; Huang, Q

Published Date

  • May 29, 2018

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 648 -

PubMed ID

  • 29844348

Pubmed Central ID

  • 29844348

Electronic International Standard Serial Number (EISSN)

  • 2041-4889

Digital Object Identifier (DOI)

  • 10.1038/s41419-018-0626-6

Language

  • eng

Conference Location

  • England