Increased plasma complement factor H is associated with geriatric depression.

Published

Journal Article

ABSTRACTBackground:Complement factor H (CFH) plays a key role in regulating the cascade of the alternative pathway of the complement system. Dysregulation of CFH may be involved in the pathophysiology of various inflammation-mediated diseases including neuropsychiatric illnesses. This study aimed to investigate this relationship by examining determining CFH levels in elderly individuals with and without depression. METHODS:A total of 152 elderly individuals (major depressive disorder (MDD) group, n = 76; comparison sample, n = 76) were selected from the Ansan Geriatric study. The plasma level of CFH was measured. MDD was diagnosed with the Mini-International Neuropsychiatric Interview as per DSM-IV criteria. The severity of depression was evaluated with the geriatric depression scale (GDS). Mean CFH levels were compared using the Mann-Whitney U test. After adjusting for possible confounding factors including age, sex, marital status, education, alcohol use, hemoglobin levels, and the Korean version of the Mini-Mental State Examination (MMSE-KC), a multiple regression analysis was conducted. The GDS score and plasma level of CFH were analyzed using Spearman's correlation. RESULTS:Plasma CFH level was significantly higher in individuals with MDD than in the comparison sample (289.51 ± 21.16 vs. 339.67 ± 66.23, p < 0.001). In a regression model adjusted for possible confounders, CFH was significantly associated with geriatric depression (p < 0.001). CFH levels were not significantly related to GDS scores in the depressed group. CONCLUSION:This study revealed an association between high plasma levels of CFH and geriatric depression, thereby suggesting the alternative pathway of the complement system contributing to the development of geriatric depression.

Full Text

Duke Authors

Cited Authors

  • Shin, C; Ham, B-J; Ko, Y-H; Pae, C-U; Park, MH; Steffens, DC; Patkar, AA; Han, C

Published Date

  • January 2019

Published In

Volume / Issue

  • 31 / 1

Start / End Page

  • 101 - 108

PubMed ID

  • 29798743

Pubmed Central ID

  • 29798743

Electronic International Standard Serial Number (EISSN)

  • 1741-203X

International Standard Serial Number (ISSN)

  • 1041-6102

Digital Object Identifier (DOI)

  • 10.1017/s1041610218000558

Language

  • eng