Mast cell activators as novel immune regulators.

Journal Article (Journal Article;Review)

Mast cells are an important cell type of the innate immune system that when activated, play a crucial role in generating protective innate host responses after bacterial and viral infection. Additionally, activated mast cells influence lymph node composition to regulate the induction of adaptive immune responses. The recognition that mast cells play a beneficial role in host responses to microbial infection and induction of adaptive immunity has provided the rationale to evaluate mast cell activators for use as antimicrobials or vaccine adjuvants. This review summarizes the role of mast cell activators in antimicrobial responses while also discussing the use of different classes of mast cell activators as potent vaccine adjuvants that enhance the induction of protective immune responses.

Full Text

Duke Authors

Cited Authors

  • Johnson-Weaver, B; Choi, HW; Abraham, SN; Staats, HF

Published Date

  • August 2018

Published In

Volume / Issue

  • 41 /

Start / End Page

  • 89 - 95

PubMed ID

  • 29843056

Pubmed Central ID

  • PMC6448149

Electronic International Standard Serial Number (EISSN)

  • 1471-4973

Digital Object Identifier (DOI)

  • 10.1016/j.coph.2018.05.004


  • eng

Conference Location

  • England