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Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.

Publication ,  Journal Article
Tedja, MS; Wojciechowski, R; Hysi, PG; Eriksson, N; Furlotte, NA; Verhoeven, VJM; Iglesias, AI; Meester-Smoor, MA; Tompson, SW; Fan, Q; Höhn, R ...
Published in: Nat Genet
June 2018

Refractive errors, including myopia, are the most frequent eye disorders worldwide and an increasingly common cause of blindness. This genome-wide association meta-analysis in 160,420 participants and replication in 95,505 participants increased the number of established independent signals from 37 to 161 and showed high genetic correlation between Europeans and Asians (>0.78). Expression experiments and comprehensive in silico analyses identified retinal cell physiology and light processing as prominent mechanisms, and also identified functional contributions to refractive-error development in all cell types of the neurosensory retina, retinal pigment epithelium, vascular endothelium and extracellular matrix. Newly identified genes implicate novel mechanisms such as rod-and-cone bipolar synaptic neurotransmission, anterior-segment morphology and angiogenesis. Thirty-one loci resided in or near regions transcribing small RNAs, thus suggesting a role for post-transcriptional regulation. Our results support the notion that refractive errors are caused by a light-dependent retina-to-sclera signaling cascade and delineate potential pathobiological molecular drivers.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

June 2018

Volume

50

Issue

6

Start / End Page

834 / 848

Location

United States

Related Subject Headings

  • White People
  • Signal Transduction
  • Retinal Pigment Epithelium
  • Retina
  • Refractive Errors
  • Polymorphism, Single Nucleotide
  • Myopia
  • Male
  • Humans
  • Genome-Wide Association Study
 

Citation

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Chicago
ICMJE
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Tedja, M. S., Wojciechowski, R., Hysi, P. G., Eriksson, N., Furlotte, N. A., Verhoeven, V. J. M., … Klaver, C. C. W. (2018). Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nat Genet, 50(6), 834–848. https://doi.org/10.1038/s41588-018-0127-7
Tedja, Milly S., Robert Wojciechowski, Pirro G. Hysi, Nicholas Eriksson, Nicholas A. Furlotte, Virginie J. M. Verhoeven, Adriana I. Iglesias, et al. “Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.Nat Genet 50, no. 6 (June 2018): 834–48. https://doi.org/10.1038/s41588-018-0127-7.
Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, et al. Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nat Genet. 2018 Jun;50(6):834–48.
Tedja, Milly S., et al. “Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.Nat Genet, vol. 50, no. 6, June 2018, pp. 834–48. Pubmed, doi:10.1038/s41588-018-0127-7.
Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, Iglesias AI, Meester-Smoor MA, Tompson SW, Fan Q, Khawaja AP, Cheng C-Y, Höhn R, Yamashiro K, Wenocur A, Grazal C, Haller T, Metspalu A, Wedenoja J, Jonas JB, Wang YX, Xie J, Mitchell P, Foster PJ, Klein BEK, Klein R, Paterson AD, Hosseini SM, Shah RL, Williams C, Teo YY, Tham YC, Gupta P, Zhao W, Shi Y, Saw W-Y, Tai E-S, Sim XL, Huffman JE, Polašek O, Hayward C, Bencic G, Rudan I, Wilson JF, CREAM Consortium, 23andMe Research Team, UK Biobank Eye and Vision Consortium, Joshi PK, Tsujikawa A, Matsuda F, Whisenhunt KN, Zeller T, van der Spek PJ, Haak R, Meijers-Heijboer H, van Leeuwen EM, Iyengar SK, Lass JH, Hofman A, Rivadeneira F, Uitterlinden AG, Vingerling JR, Lehtimäki T, Raitakari OT, Biino G, Concas MP, Schwantes-An T-H, Igo RP, Cuellar-Partida G, Martin NG, Craig JE, Gharahkhani P, Williams KM, Nag A, Rahi JS, Cumberland PM, Delcourt C, Bellenguez C, Ried JS, Bergen AA, Meitinger T, Gieger C, Wong TY, Hewitt AW, Mackey DA, Simpson CL, Pfeiffer N, Pärssinen O, Baird PN, Vitart V, Amin N, van Duijn CM, Bailey-Wilson JE, Young TL, Saw S-M, Stambolian D, MacGregor S, Guggenheim JA, Tung JY, Hammond CJ, Klaver CCW. Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nat Genet. 2018 Jun;50(6):834–848.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

June 2018

Volume

50

Issue

6

Start / End Page

834 / 848

Location

United States

Related Subject Headings

  • White People
  • Signal Transduction
  • Retinal Pigment Epithelium
  • Retina
  • Refractive Errors
  • Polymorphism, Single Nucleotide
  • Myopia
  • Male
  • Humans
  • Genome-Wide Association Study