Atypical teratoid rhabdoid tumor in a 65-year-old man presenting with disseminated leptomeningeal disease: A case report and review of the literature.

Journal Article

Central nervous system atypical teratoid rhabdoid tumors are very rare aggressive tumor of childhood, primarily occurring at age of less than 3 years old. The prognosis of these tumors is very poor, with a reported median survival of 6-12 months in most cases. Treatment typically consists of aggressive chemotherapy and radiotherapy. We present the case of a 65-year-old man who presented with progressive encephalopathy and change in personality over 3 months period. The patient had further accelerated decline over 3 weeks. The diagnosis of atypical teratoid rhabdoid tumor initially remained elusive despite very extensive workup, but was eventually confirmed via open brain biopsy. To the best of our knowledge, this is the oldest reported case of atypical teratoid rhabdoid tumor in the literature. We further extend the spectrum of this rare disease.

Full Text

Duke Authors

Cited Authors

  • Babi, M-A; Fecci, P; Luedke, M; Pineda, O; O'Keefe, YA

Published Date

  • 2018

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 2050313X18775298 -

PubMed ID

  • 29785266

Pubmed Central ID

  • PMC5954568

International Standard Serial Number (ISSN)

  • 2050-313X

Digital Object Identifier (DOI)

  • 10.1177/2050313X18775298


  • eng

Conference Location

  • England