Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines.

Journal Article (Journal Article)

Here we report highly efficient and chemoselective azadiene-imine reductive couplings catalyzed by (Ph-BPE)Cu-H that afford anti-1,2-diamines. In all cases, reactions take place with either aldimine or ketimine electrophiles to deliver a single diastereomer of product in >95:5 er. The products' diamines are easily differentiable, facilitating downstream synthesis.

Full Text

Duke Authors

Cited Authors

  • Shao, X; Li, K; Malcolmson, SJ

Published Date

  • June 2018

Published In

Volume / Issue

  • 140 / 23

Start / End Page

  • 7083 - 7087

PubMed ID

  • 29775301

Pubmed Central ID

  • PMC5999589

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/jacs.8b04750


  • eng