The nonhuman primate model of the relationship between gonadal steroids and coronary heart disease.

Journal Article (Journal Article;Review)

Experimental data derived from studies using cynomolgus macaque females provide strong evidence that estrogen influences both premenopausal and postmenopausal coronary artery atherosclerosis. Because the monkey studies are not hampered by selection bias, the data are supportive of the tentative conclusions from epidemiological studies indicating that the association between postmenopausal estrogen use and reduced coronary artery atherosclerosis is real. Present forms of HRT are not sufficiently acceptable to women to result in a compliance rate likely to affect the adverse impact of estrogen deprivation on coronary artery atherosclerosis. Nutritional supplementation may provide a more acceptable alternative.

Full Text

Duke Authors

Cited Authors

  • Clarkson, TB; Hughes, CL; Klein, KP

Published Date

  • 1995

Published In

Volume / Issue

  • 38 / 3

Start / End Page

  • 189 - 198

PubMed ID

  • 7494881

International Standard Serial Number (ISSN)

  • 0033-0620

Digital Object Identifier (DOI)

  • 10.1016/s0033-0620(95)80011-5


  • eng

Conference Location

  • United States