The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phase deficiency.

Journal Article (Journal Article)

Relatively little knowledge exists of corpus luteum function in early pregnancy after the successful treatment of ovulatory dysfunction or luteal phase deficiency. To assess the activity of the corpus luteum of such patients, human chorionic gonadotropin (hCG) and 17-hydroxyprogesterone (17-OH-P) levels were determined in serum samples obtained from normal women (44 patients), women with ovulatory dysfunction (10 patients), and women with luteal phase deficiency (7 patients); all determinations were made during conceptive cycles, and sampling continued into the first trimester of pregnancy. There were no statistically significant abnormalities of hCG levels when infertility patients were compared with control patients. According to the premise that 17-OH-P levels reflect corpus luteal function, there appeared to be adequate function in pregnancies after progesterone treatment of luteal phase deficiency. In pregnancies following ovulation induction with clomiphene, the corpus luteum function, on the basis of 17-OH-P levels, was significantly increased in magnitude and duration. These results have clinical implications with regard to supplemental hormone therapy in early pregnancy.

Full Text

Duke Authors

Cited Authors

  • Soules, MR; Hughes, CL; Aksel, S; Tyrey, L; Hammond, CB

Published Date

  • July 1, 1981

Published In

Volume / Issue

  • 36 / 1

Start / End Page

  • 31 - 36

PubMed ID

  • 7250405

International Standard Serial Number (ISSN)

  • 0015-0282

Digital Object Identifier (DOI)

  • 10.1016/s0015-0282(16)45614-1


  • eng

Conference Location

  • United States