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The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phase deficiency.

Publication ,  Journal Article
Soules, MR; Hughes, CL; Aksel, S; Tyrey, L; Hammond, CB
Published in: Fertil Steril
July 1981

Relatively little knowledge exists of corpus luteum function in early pregnancy after the successful treatment of ovulatory dysfunction or luteal phase deficiency. To assess the activity of the corpus luteum of such patients, human chorionic gonadotropin (hCG) and 17-hydroxyprogesterone (17-OH-P) levels were determined in serum samples obtained from normal women (44 patients), women with ovulatory dysfunction (10 patients), and women with luteal phase deficiency (7 patients); all determinations were made during conceptive cycles, and sampling continued into the first trimester of pregnancy. There were no statistically significant abnormalities of hCG levels when infertility patients were compared with control patients. According to the premise that 17-OH-P levels reflect corpus luteal function, there appeared to be adequate function in pregnancies after progesterone treatment of luteal phase deficiency. In pregnancies following ovulation induction with clomiphene, the corpus luteum function, on the basis of 17-OH-P levels, was significantly increased in magnitude and duration. These results have clinical implications with regard to supplemental hormone therapy in early pregnancy.

Duke Scholars

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

July 1981

Volume

36

Issue

1

Start / End Page

31 / 36

Location

United States

Related Subject Headings

  • Time Factors
  • Pregnancy
  • Ovulation Induction
  • Obstetrics & Reproductive Medicine
  • Hydroxyprogesterones
  • Humans
  • Female
  • Corpus Luteum
  • Chorionic Gonadotropin
  • Anovulation
 

Citation

APA
Chicago
ICMJE
MLA
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Soules, M. R., Hughes, C. L., Aksel, S., Tyrey, L., & Hammond, C. B. (1981). The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phase deficiency. Fertil Steril, 36(1), 31–36. https://doi.org/10.1016/s0015-0282(16)45614-1
Soules, M. R., C. L. Hughes, S. Aksel, L. Tyrey, and C. B. Hammond. “The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phase deficiency.Fertil Steril 36, no. 1 (July 1981): 31–36. https://doi.org/10.1016/s0015-0282(16)45614-1.
Soules MR, Hughes CL, Aksel S, Tyrey L, Hammond CB. The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phase deficiency. Fertil Steril. 1981 Jul;36(1):31–6.
Soules, M. R., et al. “The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phase deficiency.Fertil Steril, vol. 36, no. 1, July 1981, pp. 31–36. Pubmed, doi:10.1016/s0015-0282(16)45614-1.
Soules MR, Hughes CL, Aksel S, Tyrey L, Hammond CB. The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phase deficiency. Fertil Steril. 1981 Jul;36(1):31–36.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

July 1981

Volume

36

Issue

1

Start / End Page

31 / 36

Location

United States

Related Subject Headings

  • Time Factors
  • Pregnancy
  • Ovulation Induction
  • Obstetrics & Reproductive Medicine
  • Hydroxyprogesterones
  • Humans
  • Female
  • Corpus Luteum
  • Chorionic Gonadotropin
  • Anovulation