Application of the estrogen threshold hypothesis to the physiologic hypoestrogenemia of lactation.

Journal Article (Journal Article)

OBJECTIVE: This study determined the impact of breastfeeding on hypoestrogenic symptoms among women in the postpartum period and correlated these findings with the Estrogen Threshold Hypothesis, which postulates that the hypoestrogenic symptoms experienced are related to circulating estrogen levels. STUDY DESIGN: Using a survey instrument that combined previously validated assessments of postpartum mood changes and menopausal symptoms, women were evaluated in the immediate postpartum period, prior to hospital discharge, and at 3 and 6 weeks postpartum. Each time period was analyzed independently, in a cross-sectional design, where women were categorized as "breastfeeding" or "bottle feeding." RESULTS: Of 236 women recruited, 171 (72.5%) intended to breastfeed, and 62 (26.3%) intended to bottle feed. At both the 3- and 6-week postpartum evaluations, a similar percentage of women in the breastfeeding and bottle-feeding groups reported hot flashes. However, breastfeeding women were more likely to report vaginal dryness than those who did not breastfeed: 20/150 (13.3%) versus 3/80 (3.8%) at 3 weeks, p<0.05; 25/143 (17.5%) versus 2/87 (2.3%) at 6 weeks, p<0.001. CONCLUSIONS: The Estrogen Threshold Hypothesis accurately predicts the findings of increased reported vaginal dryness but not hot flashes during lactation.

Full Text

Duke Authors

Cited Authors

  • Agarwal, SK; Kim, J; Korst, LM; Hughes, CL

Published Date

  • March 2015

Published In

Volume / Issue

  • 10 / 2

Start / End Page

  • 77 - 83

PubMed ID

  • 25565323

Electronic International Standard Serial Number (EISSN)

  • 1556-8342

Digital Object Identifier (DOI)

  • 10.1089/bfm.2014.0030


  • eng

Conference Location

  • United States