Galactose metabolism and ovarian toxicity.

Published

Journal Article (Review)

Galactose is an energy-providing nutrient and also a necessary basic substrate for the biosynthesis of many macromolecules in the body. Metabolic pathways for galactose are important not only for the provision of these pathways but also for the prevention of galactose and galactose metabolite accumulation. Problems with galactose metabolism can cause a variety of clinical manifestations in animals and humans. It has been found that the mammalian ovary is particularly susceptible to damage from the accumulation of galactose and galactose metabolites. The galactose metabolites Gal-1-P, galactitol, and UDPgal are all considered to be important in this toxicity and proposed mechanisms include interference with ovarian apoptosis and gonadotrophin signaling. This review addresses the most recent scientific findings regarding the possible mechanisms of galactose-induced ovarian toxicity and also the possible protective role of hormonal and antioxidant therapy. In addition, the available epidemiologic and scientific evidence linking galactose intake with risk of ovarian cancer is discussed.

Full Text

Duke Authors

Cited Authors

  • Liu, G; Hale, GE; Hughes, CL

Published Date

  • September 2000

Published In

Volume / Issue

  • 14 / 5

Start / End Page

  • 377 - 384

PubMed ID

  • 11020650

Pubmed Central ID

  • 11020650

International Standard Serial Number (ISSN)

  • 0890-6238

Language

  • eng

Conference Location

  • United States