Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

Published online

Journal Article

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

Full Text

Duke Authors

Cited Authors

  • Stolk, L; Perry, JRB; Chasman, DI; He, C; Mangino, M; Sulem, P; Barbalic, M; Broer, L; Byrne, EM; Ernst, F; Esko, T; Franceschini, N; Gudbjartsson, DF; Hottenga, J-J; Kraft, P; McArdle, PF; Porcu, E; Shin, S-Y; Smith, AV; van Wingerden, S; Zhai, G; Zhuang, WV; Albrecht, E; Alizadeh, BZ; Aspelund, T; Bandinelli, S; Lauc, LB; Beckmann, JS; Boban, M; Boerwinkle, E; Broekmans, FJ; Burri, A; Campbell, H; Chanock, SJ; Chen, C; Cornelis, MC; Corre, T; Coviello, AD; d'Adamo, P; Davies, G; de Faire, U; de Geus, EJC; Deary, IJ; Dedoussis, GVZ; Deloukas, P; Ebrahim, S; Eiriksdottir, G; Emilsson, V; Eriksson, JG; Fauser, BCJM; Ferreli, L; Ferrucci, L; Fischer, K; Folsom, AR; Garcia, ME; Gasparini, P; Gieger, C; Glazer, N; Grobbee, DE; Hall, P; Haller, T; Hankinson, SE; Hass, M; Hayward, C; Heath, AC; Hofman, A; Ingelsson, E; Janssens, ACJW; Johnson, AD; Karasik, D; Kardia, SLR; Keyzer, J; Kiel, DP; Kolcic, I; Kutalik, Z; Lahti, J; Lai, S; Laisk, T; Laven, JSE; Lawlor, DA; Liu, J; Lopez, LM; Louwers, YV; Magnusson, PKE; Marongiu, M; Martin, NG; Klaric, IM; Masciullo, C; McKnight, B; Medland, SE; Melzer, D; Mooser, V; Navarro, P; Newman, AB; Nyholt, DR; Onland-Moret, NC; Palotie, A; Paré, G; Parker, AN; Pedersen, NL; Peeters, PHM; Pistis, G; Plump, AS; Polasek, O; Pop, VJM; Psaty, BM; Räikkönen, K; Rehnberg, E; Rotter, JI; Rudan, I; Sala, C; Salumets, A; Scuteri, A; Singleton, A; Smith, JA; Snieder, H; Soranzo, N; Stacey, SN; Starr, JM; Stathopoulou, MG; Stirrups, K; Stolk, RP; Styrkarsdottir, U; Sun, YV; Tenesa, A; Thorand, B; Toniolo, D; Tryggvadottir, L; Tsui, K; Ulivi, S; van Dam, RM; van der Schouw, YT; van Gils, CH; van Nierop, P; Vink, JM; Visscher, PM; Voorhuis, M; Waeber, G; Wallaschofski, H; Wichmann, HE; Widen, E; Wijnands-van Gent, CJM; Willemsen, G; Wilson, JF; Wolffenbuttel, BHR; Wright, AF; Yerges-Armstrong, LM; Zemunik, T; Zgaga, L; Zillikens, MC; Zygmunt, M; LifeLines Cohort Study, ; Arnold, AM; Boomsma, DI; Buring, JE; Crisponi, L; Demerath, EW; Gudnason, V; Harris, TB; Hu, FB; Hunter, DJ; Launer, LJ; Metspalu, A; Montgomery, GW; Oostra, BA; Ridker, PM; Sanna, S; Schlessinger, D; Spector, TD; Stefansson, K; Streeten, EA; Thorsteinsdottir, U; Uda, M; Uitterlinden, AG; van Duijn, CM; Völzke, H; Murray, A; Murabito, JM; Visser, JA; Lunetta, KL

Published Date

  • January 22, 2012

Published In

Volume / Issue

  • 44 / 3

Start / End Page

  • 260 - 268

PubMed ID

  • 22267201

Pubmed Central ID

  • 22267201

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/ng.1051

Language

  • eng

Conference Location

  • United States