Enterovirus causes rapidly progressive dementia in a 28-year-old immunosuppressed woman.

Journal Article (Journal Article)

Enterovirus in the nervous system can present with protean manifestations, including polio-like paralysis, movement disorders, and seizures. This is a report of a single case of a rapidly progressive dementing illness in a young woman with common variable immunodeficiency (CVID). Over the course of several months, she developed profound aphasia, apraxia, and cerebellar signs. She underwent brain biopsy which was suggestive of toxoplasmosis; despite an adequate course of treatment, she continued to decline and ultimately died. Autopsy and PCR testing revealed diffuse coxsackie B3 infiltration in the meninges and brain parenchyma. To our knowledge, this is the first description of enterovirus causing a dementing illness in a young immunosuppressed adult. We highlight the need for a broad differential diagnosis, especially for immunocompromised individuals, who may present in an atypical fashion.

Full Text

Duke Authors

Cited Authors

  • Mantri, S; Shah, BB

Published Date

  • August 2016

Published In

Volume / Issue

  • 22 / 4

Start / End Page

  • 538 - 540

PubMed ID

  • 26727905

Electronic International Standard Serial Number (EISSN)

  • 1538-2443

Digital Object Identifier (DOI)

  • 10.1007/s13365-015-0418-z


  • eng

Conference Location

  • United States