Genomic characterization of recurrent mold infections in thoracic transplant recipients.

Published

Journal Article

Invasive mold disease in thoracic organ transplant recipients is a well-recognized complication, but the long-term persistence of molds within the human body and evasion of host defenses has not been well-described. We present 2 cases of invasive mold disease (Verruconis gallopava and Aspergillus fumigatus) in thoracic transplant recipients who had the same mold cultured years prior to the invasive disease presentation. The paired isolates from the index and recurrent infections in both patients were compared using whole-genome sequencing to determine if the same strain of mold caused both the index and recurrent infections. In Case 1, the isolates were found to be of the same strain indicating that the initial colonizing isolate identified pre-transplant eventually caused invasive mold disease post-transplant while in Case 2, the 2 isolates were not of the same strain. These results demonstrate the distinct possibility of molds both persisting within the human body for years prior to invasive mold disease or the long-term risk of recurrent, persistent infection with more than one strain. Further studies of long-term molecular epidemiology of IMD and risk factors for mold persistence in transplant recipients are encouraged.

Full Text

Duke Authors

Cited Authors

  • Messina, JA; Wolfe, CR; Hemmersbach-Miller, M; Milano, C; Todd, JL; Reynolds, J; Alexander, BD; Schell, WA; Cuomo, CA; Perfect, JR

Published Date

  • October 2018

Published In

Volume / Issue

  • 20 / 5

Start / End Page

  • e12935 -

PubMed ID

  • 29851203

Pubmed Central ID

  • 29851203

Electronic International Standard Serial Number (EISSN)

  • 1399-3062

International Standard Serial Number (ISSN)

  • 1398-2273

Digital Object Identifier (DOI)

  • 10.1111/tid.12935

Language

  • eng