Flow Cytometry for the Immunotoxicologist.


Journal Article

Assessing the immunotoxicity of xenobiotics by current regulatory testing has revealed compounds that can cause immunosuppression and stimulation. Flow cytometry is a cutting edge technique that can provide data on how toxicants can alter the quality and quantity of the immune response after exposure. Here we describe protocols for how to use flow cytometry to measure the immune response in multiple rodent organs (blood and lymphoid and nonlymphoid) as well as in novel models recently being utilized in the field of toxicology. These methods can be used for current testing and to determine mechanisms by which a xenobiotic can cause immunotoxicity.

Full Text

Duke Authors

Cited Authors

  • Espenschied, ST; Tighe, RM; Gowdy, KM

Published Date

  • January 2018

Published In

Volume / Issue

  • 1803 /

Start / End Page

  • 183 - 197

PubMed ID

  • 29882140

Pubmed Central ID

  • 29882140

Electronic International Standard Serial Number (EISSN)

  • 1940-6029

International Standard Serial Number (ISSN)

  • 1064-3745

Digital Object Identifier (DOI)

  • 10.1007/978-1-4939-8549-4_12


  • eng