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Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.

Publication ,  Journal Article
Ganley, JG; Carr, G; Ioerger, TR; Sacchettini, JC; Clardy, J; Derbyshire, ER
Published in: Chembiochem : a European journal of chemical biology
August 2018

The Anopheles mosquito that harbors the Plasmodium parasite contains a microbiota that can influence both the vector and the parasite. In recent years, insect-associated microbes have highlighted the untapped potential of exploiting interspecies interactions to discover bioactive compounds. In this study, we report the discovery of nonribosomal lipodepsipeptides that are produced by a Serratia sp. within the midgut and salivary glands of Anopheles stephensi mosquitoes. The lipodepsipeptides, stephensiolides A-K, have antibiotic activity and facilitate bacterial surface motility. Bioinformatic analyses indicate that the stephensiolides are ubiquitous in nature and are likely important for Serratia spp. colonization within mosquitoes, humans, and other ecological niches. Our results demonstrate the usefulness of probing insect-microbiome interactions, enhance our understanding of the chemical ecology within Anopheles mosquitoes, and provide a secondary-metabolite scaffold for further investigate of this complex relationship.

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Published In

Chembiochem : a European journal of chemical biology

DOI

EISSN

1439-7633

ISSN

1439-4227

Publication Date

August 2018

Volume

19

Issue

15

Start / End Page

1590 / 1594

Related Subject Headings

  • Serratia
  • Plasmodium falciparum
  • Organic Chemistry
  • Mosquito Vectors
  • Malaria, Falciparum
  • Malaria
  • Lipopeptides
  • Humans
  • Hep G2 Cells
  • Depsipeptides
 

Citation

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Ganley, J. G., Carr, G., Ioerger, T. R., Sacchettini, J. C., Clardy, J., & Derbyshire, E. R. (2018). Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. Chembiochem : A European Journal of Chemical Biology, 19(15), 1590–1594. https://doi.org/10.1002/cbic.201800124
Ganley, Jack G., Gavin Carr, Thomas R. Ioerger, James C. Sacchettini, Jon Clardy, and Emily R. Derbyshire. “Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.Chembiochem : A European Journal of Chemical Biology 19, no. 15 (August 2018): 1590–94. https://doi.org/10.1002/cbic.201800124.
Ganley JG, Carr G, Ioerger TR, Sacchettini JC, Clardy J, Derbyshire ER. Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. Chembiochem : a European journal of chemical biology. 2018 Aug;19(15):1590–4.
Ganley, Jack G., et al. “Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.Chembiochem : A European Journal of Chemical Biology, vol. 19, no. 15, Aug. 2018, pp. 1590–94. Epmc, doi:10.1002/cbic.201800124.
Ganley JG, Carr G, Ioerger TR, Sacchettini JC, Clardy J, Derbyshire ER. Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. Chembiochem : a European journal of chemical biology. 2018 Aug;19(15):1590–1594.
Journal cover image

Published In

Chembiochem : a European journal of chemical biology

DOI

EISSN

1439-7633

ISSN

1439-4227

Publication Date

August 2018

Volume

19

Issue

15

Start / End Page

1590 / 1594

Related Subject Headings

  • Serratia
  • Plasmodium falciparum
  • Organic Chemistry
  • Mosquito Vectors
  • Malaria, Falciparum
  • Malaria
  • Lipopeptides
  • Humans
  • Hep G2 Cells
  • Depsipeptides