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Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease.

Publication ,  Journal Article
Grady, ST; Koutrakis, P; Hart, JE; Coull, BA; Schwartz, J; Laden, F; Zhang, JJ; Gong, J; Moy, ML; Garshick, E
Published in: Environment international
June 2018

We assessed relationships between indoor black carbon (BC) exposure and urinary oxidative stress biomarkers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in participants with chronic obstructive pulmonary disease (COPD).Eighty-two participants completed in-home air sampling for one week prior to providing urine samples up to four times in a year. Weekly indoor and daily outdoor concentrations were used to estimate indoor daily lags and moving averages. There were no reported in-home BC sources, thus indoor levels closely represented outdoor BC infiltration. Mixed effects regression models with a random intercept for each participant were used to assess relationships between indoor BC and 8-OHdG and MDA, adjusting for age, race, BMI, diabetes, heart disease, season, time of urine collection, urine creatinine, and outdoor humidity and temperature.There were positive effects of BC on 8-OHdG and MDA, with the greatest effect the day before urine collection (6.9% increase; 95% CI 0.9-13.3%, per interquartile range: 0.22 μg/m3) for 8-OHdG and 1 to 4 days before collection (8.3% increase; 95% CI 0.03-17.3% per IQR) for MDA. Results were similar in models adjusting for PM2.5 not associated with BC and NO2 (10.4% increase, 95% CI: 3.5-17.9 for 8-OHdG; 8.1% increase, 95% CI: -1.1-18.1 for MDA). Effects on 8-OHdG were greater in obese participants.We found positive associations between BC exposure and 8-OHdG and MDA, in which associations with 8-OHdG were stronger in obese participants. These results suggest that exposure to low levels of traffic-related pollution results in lipid peroxidation and oxidative DNA damage in individuals with COPD.

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Published In

Environment international

DOI

EISSN

1873-6750

ISSN

0160-4120

Publication Date

June 2018

Volume

115

Start / End Page

188 / 195

Related Subject Headings

  • Soot
  • Pulmonary Disease, Chronic Obstructive
  • Oxidative Stress
  • Humans
  • Environmental Sciences
  • Cohort Studies
  • Biomarkers
  • Air Pollutants
 

Citation

APA
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Grady, S. T., Koutrakis, P., Hart, J. E., Coull, B. A., Schwartz, J., Laden, F., … Garshick, E. (2018). Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease. Environment International, 115, 188–195. https://doi.org/10.1016/j.envint.2018.02.040
Grady, Stephanie T., Petros Koutrakis, Jaime E. Hart, Brent A. Coull, Joel Schwartz, Francine Laden, Junfeng Jim Zhang, Jicheng Gong, Marilyn L. Moy, and Eric Garshick. “Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease.Environment International 115 (June 2018): 188–95. https://doi.org/10.1016/j.envint.2018.02.040.
Grady ST, Koutrakis P, Hart JE, Coull BA, Schwartz J, Laden F, et al. Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease. Environment international. 2018 Jun;115:188–95.
Grady, Stephanie T., et al. “Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease.Environment International, vol. 115, June 2018, pp. 188–95. Epmc, doi:10.1016/j.envint.2018.02.040.
Grady ST, Koutrakis P, Hart JE, Coull BA, Schwartz J, Laden F, Zhang JJ, Gong J, Moy ML, Garshick E. Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease. Environment international. 2018 Jun;115:188–195.
Journal cover image

Published In

Environment international

DOI

EISSN

1873-6750

ISSN

0160-4120

Publication Date

June 2018

Volume

115

Start / End Page

188 / 195

Related Subject Headings

  • Soot
  • Pulmonary Disease, Chronic Obstructive
  • Oxidative Stress
  • Humans
  • Environmental Sciences
  • Cohort Studies
  • Biomarkers
  • Air Pollutants