Oseltamivir resistance during treatment of influenza A (H5N1) infection.


Journal Article

Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) virus infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. These observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents.

Full Text

Cited Authors

  • de Jong, MD; Tran, TT; Truong, HK; Vo, MH; Smith, GJD; Nguyen, VC; Bach, VC; Phan, TQ; Do, QH; Guan, Y; Peiris, JSM; Tran, TH; Farrar, J

Published Date

  • December 2005

Published In

Volume / Issue

  • 353 / 25

Start / End Page

  • 2667 - 2672

PubMed ID

  • 16371632

Pubmed Central ID

  • 16371632

Electronic International Standard Serial Number (EISSN)

  • 1533-4406

International Standard Serial Number (ISSN)

  • 0028-4793

Digital Object Identifier (DOI)

  • 10.1056/nejmoa054512


  • eng