Gene flow and competitive exclusion of avian influenza A virus in natural reservoir hosts.


Journal Article

Geographical separation of host species has shaped the avian influenza A virus gene pool into independently evolving Eurasian and American lineages, although phylogenetic evidence for gene flow and reassortment indicates that these lineages also mix on occasion. While the evolutionary dynamics of the avian influenza gene pool have been described, the consequences of gene flow on virus evolution and population structure in this system have not been investigated. Here we show that viral gene flow from Eurasia has led to the replacement of endemic avian influenza viruses in North America, likely through competition for susceptible hosts. This competition is characterized by changes in rates of nucleotide substitution and selection pressures. However, the discontinuous distribution of susceptible hosts may produce long periods of co-circulation of competing virus strains before lineage extinction occurs. These results also suggest that viral competition for host resources may be an important mechanism in disease emergence.

Full Text

Cited Authors

  • Bahl, J; Vijaykrishna, D; Holmes, EC; Smith, GJD; Guan, Y

Published Date

  • August 2009

Published In

Volume / Issue

  • 390 / 2

Start / End Page

  • 289 - 297

PubMed ID

  • 19501380

Pubmed Central ID

  • 19501380

Electronic International Standard Serial Number (EISSN)

  • 1096-0341

International Standard Serial Number (ISSN)

  • 2514-4138

Digital Object Identifier (DOI)

  • 10.1016/j.virol.2009.05.002


  • eng