Distribution of amantadine-resistant H5N1 avian influenza variants in Asia.


Journal Article

We examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated in Indonesia (6.3% of isolates) and China (8.9% of isolates), where human infection was recently reported. The dual mutation motif Leu26Ile-Ser31Asn (leucine-->isoleucine at aa 26 and serine-->asparagine at aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations.

Full Text

Cited Authors

  • Cheung, C-L; Rayner, JM; Smith, GJD; Wang, P; Naipospos, TSP; Zhang, J; Yuen, K-Y; Webster, RG; Peiris, JSM; Guan, Y; Chen, H

Published Date

  • June 2006

Published In

Volume / Issue

  • 193 / 12

Start / End Page

  • 1626 - 1629

PubMed ID

  • 16703504

Pubmed Central ID

  • 16703504

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/504723


  • eng