A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors.

Published

Journal Article

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

Full Text

Duke Authors

Cited Authors

  • Choi, M-R; Stanton-Maxey, KJ; Stanley, JK; Levin, CS; Bardhan, R; Akin, D; Badve, S; Sturgis, J; Robinson, JP; Bashir, R; Halas, NJ; Clare, SE

Published Date

  • December 2007

Published In

Volume / Issue

  • 7 / 12

Start / End Page

  • 3759 - 3765

PubMed ID

  • 17979310

Pubmed Central ID

  • 17979310

Electronic International Standard Serial Number (EISSN)

  • 1530-6992

International Standard Serial Number (ISSN)

  • 1530-6984

Digital Object Identifier (DOI)

  • 10.1021/nl072209h

Language

  • eng