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The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients.

Publication ,  Journal Article
Wang, X-F; Zhu, Y-T; Wang, J-J; Zeng, D-X; Mu, C-Y; Chen, Y-B; Lei, W; Zhu, Y-H; Huang, J-A
Published in: PLoS One
2017

BACKGROUND: Interleukin-17 (IL-17) plays an important role in cancer progression. Previous studies remained controversial regarding the correlation between IL-17 expression and lung cancer (LC) prognosis. To comprehensively and quantitatively summarize the prognostic value of IL-17 expression in LC patients, a systematic review and meta-analysis were performed. METHODS: We identified the relevant literatures by searching the PubMed, EMBASE, Cochrane Library, SinoMed, China National Knowledge Infrastructure (CNKI) and Wanfang Data databases, up until April 1, 2017. Overall survival (OS), disease free survival (DFS) and clinicopathological characteristics were collected from relevant studies. Pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI) were calculated to estimate the effective value of IL-17 expression on clinical outcomes. RESULTS: Six studies containing 479 Chinese LC patients were involved in this meta-analysis. The results indicated high IL-17 expression was independently correlated with poorer OS (HR = 1.82, 95% CI 1.44-2.29, P < 0.00001) and shorter DFS (HR = 2.41, 95% CI 1.42-4.08, P = 0.001) in LC patients. Further, when stratified by LC histological type (non-small cell lung cancer and small cell lung cancer), tumor stage (Ⅰ-Ⅲ,Ⅰ-Ⅳ and Ⅳ), detection specimen (serum, intratumoral tissue and pleural effusion), test method (immunological histological chemistry and enzyme linked immunosorbent assay), and HR estimated method (reported and estimated), all of the results were statistically significant. These data indicated that elevated IL-17 expression is correlated with poor clinical outcomes in LC. The meta-analysis did not show heterogeneity or publication bias. CONCLUSIONS: The present meta-analysis revealed that high IL-17 expression was an indicator of poor prognosis for Chinese patients with LC. It could potentially help to assess patients' prognosis and estimate treatment efficacy in therapeutic interventions.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

9

Start / End Page

e0185168

Location

United States

Related Subject Headings

  • Prognosis
  • Lung Neoplasms
  • Interleukin-17
  • Humans
  • General Science & Technology
  • Gene Expression Regulation, Neoplastic
  • China
 

Citation

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Wang, X.-F., Zhu, Y.-T., Wang, J.-J., Zeng, D.-X., Mu, C.-Y., Chen, Y.-B., … Huang, J.-A. (2017). The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients. PLoS One, 12(9), e0185168. https://doi.org/10.1371/journal.pone.0185168
Wang, Xiao-Fei, Yi-Tong Zhu, Jia-Jia Wang, Da-Xiong Zeng, Chuan-Yong Mu, Yan-Bin Chen, Wei Lei, Ye-Han Zhu, and Jian-An Huang. “The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients.PLoS One 12, no. 9 (2017): e0185168. https://doi.org/10.1371/journal.pone.0185168.
Wang X-F, Zhu Y-T, Wang J-J, Zeng D-X, Mu C-Y, Chen Y-B, et al. The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients. PLoS One. 2017;12(9):e0185168.
Wang, Xiao-Fei, et al. “The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients.PLoS One, vol. 12, no. 9, 2017, p. e0185168. Pubmed, doi:10.1371/journal.pone.0185168.
Wang X-F, Zhu Y-T, Wang J-J, Zeng D-X, Mu C-Y, Chen Y-B, Lei W, Zhu Y-H, Huang J-A. The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients. PLoS One. 2017;12(9):e0185168.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

9

Start / End Page

e0185168

Location

United States

Related Subject Headings

  • Prognosis
  • Lung Neoplasms
  • Interleukin-17
  • Humans
  • General Science & Technology
  • Gene Expression Regulation, Neoplastic
  • China