Photoacoustic microscopy: principles and biomedical applications.


Journal Article (Review)

Photoacoustic microscopy (PAM) has become an increasingly popular technology for biomedical applications, providing anatomical, functional, and molecular information. In this concise review, we first introduce the basic principles and typical system designs of PAM, including optical-resolution PAM and acoustic-resolution PAM. The major imaging characteristics of PAM, i.e. spatial resolutions, penetration depth, and scanning approach are discussed in detail. Then, we introduce the major biomedical applications of PAM, including anatomical imaging across scales from cellular level to organismal level, label-free functional imaging using endogenous biomolecules, and molecular imaging using exogenous contrast agents. Lastly, we discuss the technical and engineering challenges of PAM in the translation to potential clinical impacts.

Full Text

Duke Authors

Cited Authors

  • Liu, W; Yao, J

Published Date

  • May 2018

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 203 - 213

PubMed ID

  • 30603203

Pubmed Central ID

  • 30603203

Electronic International Standard Serial Number (EISSN)

  • 2093-985X

International Standard Serial Number (ISSN)

  • 2093-9868

Digital Object Identifier (DOI)

  • 10.1007/s13534-018-0067-2


  • eng