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Major depression, antidepressant use, and male and female fertility.

Publication ,  Journal Article
Evans-Hoeker, EA; Eisenberg, E; Diamond, MP; Legro, RS; Alvero, R; Coutifaris, C; Casson, PR; Christman, GM; Hansen, KR; Zhang, H; Santoro, N ...
Published in: Fertility and sterility
May 2018

To determine if maternal major depression (MD), antidepressant use, or paternal MD are associated with pregnancy outcomes after non-IVF fertility treatments.Cohort study.Clinics.Participants in two randomized trials: PPCOS II (clomiphene citrate versus letrozole for polycystic ovary syndrome), and AMIGOS (gonadotropins versus clomiphene citrate versus letrozole for unexplained infertility).Female and male partners completed the Patient Health Questionnaire (PHQ-9). Female medication use was collected. PHQ-9 score ≥10 was used to define currently active MD.Primary outcome: live birth.pregnancy, first-trimester miscarriage. Poisson regression models were used to determine relative risks after adjusting for age, race, income, months trying to conceive, smoking, and study (PPCOS II versus AMIGOS).Data for 1,650 women and 1,608 men were included. Among women not using an antidepressant, the presence of currently active MD was not associated with poorer fertility outcomes (live birth, miscarriage), but rather was associated with a slightly increased likelihood of pregnancy. Maternal antidepressant use (n = 90) was associated with increased risk of miscarriage, and male partners with currently active MD were less likely to achieve conception.Currently active MD in the female partner does not negatively affect non-IVF treatment outcomes; however, currently active MD in the male partner may lower the likelihood of pregnancy. Maternal antidepressant use is associated with first-trimester pregnancy loss, which may depend upon the type of antidepressant.NCT00719186 and NCT01044862.

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Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

May 2018

Volume

109

Issue

5

Start / End Page

879 / 887

Related Subject Headings

  • Young Adult
  • Obstetrics & Reproductive Medicine
  • Male
  • Infertility, Male
  • Infertility, Female
  • Humans
  • Fertility
  • Female
  • Depressive Disorder, Major
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Evans-Hoeker, E. A., Eisenberg, E., Diamond, M. P., Legro, R. S., Alvero, R., Coutifaris, C., … Reproductive Medicine Network, . (2018). Major depression, antidepressant use, and male and female fertility. Fertility and Sterility, 109(5), 879–887. https://doi.org/10.1016/j.fertnstert.2018.01.029
Evans-Hoeker, Emily A., Esther Eisenberg, Michael P. Diamond, Richard S. Legro, Ruben Alvero, Christos Coutifaris, Peter R. Casson, et al. “Major depression, antidepressant use, and male and female fertility.Fertility and Sterility 109, no. 5 (May 2018): 879–87. https://doi.org/10.1016/j.fertnstert.2018.01.029.
Evans-Hoeker EA, Eisenberg E, Diamond MP, Legro RS, Alvero R, Coutifaris C, et al. Major depression, antidepressant use, and male and female fertility. Fertility and sterility. 2018 May;109(5):879–87.
Evans-Hoeker, Emily A., et al. “Major depression, antidepressant use, and male and female fertility.Fertility and Sterility, vol. 109, no. 5, May 2018, pp. 879–87. Epmc, doi:10.1016/j.fertnstert.2018.01.029.
Evans-Hoeker EA, Eisenberg E, Diamond MP, Legro RS, Alvero R, Coutifaris C, Casson PR, Christman GM, Hansen KR, Zhang H, Santoro N, Steiner AZ, Reproductive Medicine Network. Major depression, antidepressant use, and male and female fertility. Fertility and sterility. 2018 May;109(5):879–887.
Journal cover image

Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

May 2018

Volume

109

Issue

5

Start / End Page

879 / 887

Related Subject Headings

  • Young Adult
  • Obstetrics & Reproductive Medicine
  • Male
  • Infertility, Male
  • Infertility, Female
  • Humans
  • Fertility
  • Female
  • Depressive Disorder, Major
  • Cohort Studies