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Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients.

Publication ,  Conference
Reinsmoen, NL; Jackson, A; Hertz, M; Savik, K; Kubo, S; Ormaza, S; Miller, L; McSherry, C
Published in: J Leukoc Biol
August 1999

We have been investigating two parameters, donor antigen-specific hyporeactivity and peripheral blood allogeneic microchimerism, to determine whether these parameters will predict a chronic rejection-free state and which recipients may be candidates for steroid withdrawal. We have identified donor antigen-specific hyporeactivity for 33% (16/48) of lung and 23% (11/47) of heart recipients. For both organ groups, the hyporeactive subgroup experienced a lower incidence of chronic rejection. The probability of donor antigen-specific hyporeactivity predicting a chronic rejection-free state is 100% for lung and 91% for heart recipients. We have identified peripheral blood allogeneic microchimerism for 77% (20/26) of lung and 36% (9/25) of heart recipients tested at 12-18 months posttransplant. Donor antigen-specific hyporeactivity correlates with a critical level of donor cells in lung recipients; the probability of high peripheral blood allogeneic microchimerism levels predicting a chronic rejection-free state in lung recipients is 100%. The results in heart recipients are not as clear with a short-, but not long-term, trend of higher chimerism levels correlating with the development of donor antigen-specific hyporeactivity. These results illustrate the usefulness of immmune parameters to predict long-term graft outcome in an organ-specific manner.

Duke Scholars

Published In

J Leukoc Biol

DOI

ISSN

0741-5400

Publication Date

August 1999

Volume

66

Issue

2

Start / End Page

306 / 309

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Chimera
  • Lung Transplantation
  • Immunology
  • Humans
  • Heart Transplantation
  • Bronchiolitis Obliterans
  • 3204 Immunology
  • 1107 Immunology
  • 0601 Biochemistry and Cell Biology
 

Citation

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MLA
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Reinsmoen, N. L., Jackson, A., Hertz, M., Savik, K., Kubo, S., Ormaza, S., … McSherry, C. (1999). Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients. In J Leukoc Biol (Vol. 66, pp. 306–309). England. https://doi.org/10.1002/jlb.66.2.306
Reinsmoen, N. L., A. Jackson, M. Hertz, K. Savik, S. Kubo, S. Ormaza, L. Miller, and C. McSherry. “Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients.” In J Leukoc Biol, 66:306–9, 1999. https://doi.org/10.1002/jlb.66.2.306.
Reinsmoen NL, Jackson A, Hertz M, Savik K, Kubo S, Ormaza S, et al. Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients. In: J Leukoc Biol. 1999. p. 306–9.
Reinsmoen, N. L., et al. “Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients.J Leukoc Biol, vol. 66, no. 2, 1999, pp. 306–09. Pubmed, doi:10.1002/jlb.66.2.306.
Reinsmoen NL, Jackson A, Hertz M, Savik K, Kubo S, Ormaza S, Miller L, McSherry C. Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients. J Leukoc Biol. 1999. p. 306–309.

Published In

J Leukoc Biol

DOI

ISSN

0741-5400

Publication Date

August 1999

Volume

66

Issue

2

Start / End Page

306 / 309

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Chimera
  • Lung Transplantation
  • Immunology
  • Humans
  • Heart Transplantation
  • Bronchiolitis Obliterans
  • 3204 Immunology
  • 1107 Immunology
  • 0601 Biochemistry and Cell Biology