Inability of Simian Virus 40 To Establish Productive Infection of Lymphoblastic Cell Lines

Journal Article

ABSTRACT Lymphoblastic cell lines were infected with simian virus 40 (SV40) and then monitored for evidence of a productive infection. No evidence of early gene expression was found 2 days following infection, as determined by assaying viral mRNAs and early antigens. Furthermore, only small amounts of virus could be detected by plaque assay 2 days after infection, and levels slowly declined until they were undetectable after a few weeks in culture. Thus, human lymphocytes are not readily infectible with SV40 and do not provide a simple model for studying interactions of SV40 with a human cell type.

Full Text

Duke Authors

Cited Authors

  • Shaikh, S; Skoczylas, C; Longnecker, R; Rundell, K

Published Date

  • May 2004

Published In

Volume / Issue

  • 78 / 9

Start / End Page

  • 4917 - 4920

Published By

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.78.9.4917-4920.2004


  • en