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The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis

Publication ,  Journal Article
Anderson, WH; Coakley, RD; Button, B; Henderson, AG; Zeman, KL; Alexis, NE; Peden, DB; Lazarowski, ER; Davis, CW; Bailey, S; Fuller, F ...
Published in: American Journal of Respiratory and Critical Care Medicine
2015

RATIONALE: Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part due to abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. OBJECTIVES: We tested the hypothesis that CB is characterized by mucus hyperconcentration, increased mucus partial osmotic pressures, and reduced mucus clearance. METHODS: We measured in CB subjects as compared to normal and asymptomatic smoking controls: 1) indices of mucus concentration (hydration), i.e., % solids; and 2) sputum adenine nucleotide/nucleoside (NT/NS) concentrations. In addition, sputum partial osmotic pressures and mucus transport rates were measured in CB subjects. MEASUREMENTS AND RESULTS: CB secretions were hyperconcentrated as indexed by an increase in % solids and total mucins, in part reflecting decreased extracellular NT/NS concentrations. CB mucus generated concentration-dependent increases in partial osmotic pressures into ranges predicted to reduce mucus transport. Mucociliary clearance (MCC) in CB subjects was negatively correlated with mucus concentration (% solids). As a test of relationships between mucus concentration and disease, mucus concentrations and MCC were compared to FEV1 and both were significantly correlated. CONCLUSIONS: Abnormal regulation of airway surface hydration may slow MCC in CB and contribute to disease pathogenesis.

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Published In

American Journal of Respiratory and Critical Care Medicine

DOI

ISSN

1535-4970

Publication Date

2015

Related Subject Headings

  • Respiratory System
  • 11 Medical and Health Sciences
 

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Anderson, W. H., Coakley, R. D., Button, B., Henderson, A. G., Zeman, K. L., Alexis, N. E., … Boucher, R. C. (2015). The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201412-2230OC
Anderson, Wayne H., Raymond D. Coakley, Brian Button, Ashley G. Henderson, Kirby L. Zeman, Neil E. Alexis, David B. Peden, et al. “The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis.” American Journal of Respiratory and Critical Care Medicine, 2015. https://doi.org/10.1164/rccm.201412-2230OC.
Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, et al. The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis. American Journal of Respiratory and Critical Care Medicine. 2015;
Anderson, Wayne H., et al. “The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis.” American Journal of Respiratory and Critical Care Medicine, 2015. Manual, doi:10.1164/rccm.201412-2230OC.
Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC. The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis. American Journal of Respiratory and Critical Care Medicine. 2015;

Published In

American Journal of Respiratory and Critical Care Medicine

DOI

ISSN

1535-4970

Publication Date

2015

Related Subject Headings

  • Respiratory System
  • 11 Medical and Health Sciences