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A Paradigm Shift on the Question of B Cells in Transplantation? Recent Insights on Regulating the Alloresponse.

Publication ,  Journal Article
Firl, DJ; Benichou, G; Kim, JI; Yeh, H
Published in: Frontiers in immunology
January 2017

B lymphocytes contribute to acute and chronic allograft rejection through their production of donor-specific antibodies (DSAs). In addition, B cells present allopeptides bound to self-MHC class II molecules and provide costimulation signals to T cells, which are essential to their activation and differentiation into memory T cells. On the other hand, both in laboratory rodents and patients, the concept of effector T cell regulation by B cells is gaining traction in the field of transplantation. Specifically, clinical trials using anti-CD20 monoclonal antibodies to deplete B cells and reverse DSA had a deleterious effect on rates of acute cellular rejection; a peculiar finding that calls into question a central paradigm in transplantation. Additional work in humans has characterized IL-10-producing B cells (IgM memory and transitional B cells), which suppress the proliferation and inflammatory cytokine productions of effector T cells in vitro. Understanding the mechanisms of regulating the alloresponse is critical if we are to achieve operational tolerance across transplantation. This review will focus on recent evidence in murine and human transplantation with respect to non-traditional roles for B cells in determining clinical outcomes.

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Published In

Frontiers in immunology

DOI

EISSN

1664-3224

ISSN

1664-3224

Publication Date

January 2017

Volume

8

Start / End Page

80

Related Subject Headings

  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 1107 Immunology
 

Citation

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Firl, D. J., Benichou, G., Kim, J. I., & Yeh, H. (2017). A Paradigm Shift on the Question of B Cells in Transplantation? Recent Insights on Regulating the Alloresponse. Frontiers in Immunology, 8, 80. https://doi.org/10.3389/fimmu.2017.00080
Firl, Daniel J., Gilles Benichou, James I. Kim, and Heidi Yeh. “A Paradigm Shift on the Question of B Cells in Transplantation? Recent Insights on Regulating the Alloresponse.Frontiers in Immunology 8 (January 2017): 80. https://doi.org/10.3389/fimmu.2017.00080.
Firl DJ, Benichou G, Kim JI, Yeh H. A Paradigm Shift on the Question of B Cells in Transplantation? Recent Insights on Regulating the Alloresponse. Frontiers in immunology. 2017 Jan;8:80.
Firl, Daniel J., et al. “A Paradigm Shift on the Question of B Cells in Transplantation? Recent Insights on Regulating the Alloresponse.Frontiers in Immunology, vol. 8, Jan. 2017, p. 80. Epmc, doi:10.3389/fimmu.2017.00080.
Firl DJ, Benichou G, Kim JI, Yeh H. A Paradigm Shift on the Question of B Cells in Transplantation? Recent Insights on Regulating the Alloresponse. Frontiers in immunology. 2017 Jan;8:80.

Published In

Frontiers in immunology

DOI

EISSN

1664-3224

ISSN

1664-3224

Publication Date

January 2017

Volume

8

Start / End Page

80

Related Subject Headings

  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 1107 Immunology