External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.

Journal Article (Journal Article)

Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.

Full Text

Duke Authors

Cited Authors

  • Ge, S; Beechinor, RJ; Hornik, CP; Standing, JF; Zimmerman, K; Cohen-Wolkowiez, M; Laughon, MM; Clark, R; Gonzalez, D

Published Date

  • September 2018

Published In

Volume / Issue

  • 62 / 9

PubMed ID

  • 29914947

Pubmed Central ID

  • PMC6125537

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

Digital Object Identifier (DOI)

  • 10.1128/AAC.00669-18


  • eng

Conference Location

  • United States