External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.
Journal Article (Journal Article)
Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.
Full Text
Duke Authors
Cited Authors
- Ge, S; Beechinor, RJ; Hornik, CP; Standing, JF; Zimmerman, K; Cohen-Wolkowiez, M; Laughon, MM; Clark, R; Gonzalez, D
Published Date
- September 2018
Published In
Volume / Issue
- 62 / 9
PubMed ID
- 29914947
Pubmed Central ID
- PMC6125537
Electronic International Standard Serial Number (EISSN)
- 1098-6596
Digital Object Identifier (DOI)
- 10.1128/AAC.00669-18
Language
- eng
Conference Location
- United States