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Best practices and lessons learned from reuse of 4 patient-derived metabolomics datasets in Alzheimer's disease.

Publication ,  Conference
Tenenbaum, JD; Blach, C
Published in: Pac Symp Biocomput
2018

The importance of open data has been increasingly recognized in recent years. Although the sharing and reuse of clinical data for translational research lags behind best practices in biological science, a number of patient-derived datasets exist and have been published enabling translational research spanning multiple scales from molecular to organ level, and from patients to populations. In seeking to replicate metabolomic biomarker results in Alzheimer's disease our team identified three independent cohorts in which to compare findings. Accessing the datasets associated with these cohorts, understanding their content and provenance, and comparing variables between studies was a valuable exercise in exploring the principles of open data in practice. It also helped inform steps taken to make the original datasets available for use by other researchers. In this paper we describe best practices and lessons learned in attempting to identify, access, understand, and analyze these additional datasets to advance research reproducibility, as well as steps taken to facilitate sharing of our own data.

Duke Scholars

Published In

Pac Symp Biocomput

EISSN

2335-6936

Publication Date

2018

Volume

23

Start / End Page

280 / 291

Location

United States

Related Subject Headings

  • Metabolomics
  • Information Dissemination
  • Humans
  • Databases, Factual
  • Computational Biology
  • Biomarkers
  • Alzheimer Disease
 

Citation

APA
Chicago
ICMJE
MLA
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Tenenbaum, J. D., & Blach, C. (2018). Best practices and lessons learned from reuse of 4 patient-derived metabolomics datasets in Alzheimer's disease. In Pac Symp Biocomput (Vol. 23, pp. 280–291). United States.
Tenenbaum, Jessica D., and Colette Blach. “Best practices and lessons learned from reuse of 4 patient-derived metabolomics datasets in Alzheimer's disease.” In Pac Symp Biocomput, 23:280–91, 2018.
Tenenbaum, Jessica D., and Colette Blach. “Best practices and lessons learned from reuse of 4 patient-derived metabolomics datasets in Alzheimer's disease.Pac Symp Biocomput, vol. 23, 2018, pp. 280–91.

Published In

Pac Symp Biocomput

EISSN

2335-6936

Publication Date

2018

Volume

23

Start / End Page

280 / 291

Location

United States

Related Subject Headings

  • Metabolomics
  • Information Dissemination
  • Humans
  • Databases, Factual
  • Computational Biology
  • Biomarkers
  • Alzheimer Disease