Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies.

Published

Journal Article (Review)

Allergic contact dermatitis (ACD) is a common skin disease that results in significant cost and morbidity. Despite its high prevalence, therapeutic options are limited. Allergic contact dermatitis is regulated primarily by T cells within the adaptive immune system, but also by natural killer and innate lymphoid cells within the innate immune system. The chemokine receptor system, consisting of chemokine peptides and chemokine G protein-coupled receptors, is a critical regulator of inflammatory processes such as ACD. Specific chemokine signaling pathways are selectively up-regulated in ACD, most prominently CXCR3 and its endogenous chemokines CXCL9, CXCL10, and CXCL11. Recent research demonstrates that these 3 chemokines are not redundant and indeed activate distinct intracellular signaling profiles such as those activated by heterotrimeric G proteins and β-arrestin adapter proteins. Such differential signaling provides an attractive therapeutic target for novel therapies for ACD and other inflammatory diseases.

Full Text

Duke Authors

Cited Authors

  • Smith, JS; Rajagopal, S; Atwater, AR

Published Date

  • July 2018

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 179 - 186

PubMed ID

  • 29939854

Pubmed Central ID

  • 29939854

Electronic International Standard Serial Number (EISSN)

  • 2162-5220

International Standard Serial Number (ISSN)

  • 1710-3568

Digital Object Identifier (DOI)

  • 10.1097/DER.0000000000000391

Language

  • eng