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"Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.

Publication ,  Journal Article
Arbeev, KG; Ukraintseva, SV; Bagley, O; Zhbannikov, IY; Cohen, AA; Kulminski, AM; Yashin, AI
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
March 2019

Recently suggested novel implementation of the statistical distance measure (DM) for evaluating "physiological dysregulation" (PD) in aging individuals (based on measuring deviations of multiple biomarkers from baseline or normal physiological states) allows reducing high-dimensional biomarker space into a single PD estimate. Here we constructed DM using biomarker profiles from FRAMCOHORT (Framingham Heart Study) and CHS (Cardiovascular Health Study) Research Materials obtained from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center, and estimated effect of PD on total survival, onset of unhealthy life (proxy for "robustness") and survival following the onset of unhealthy life (proxy for "resilience"). We investigated relationships between PD and declines in stress resistance and adaptive capacity not directly observed in data. PD was more strongly associated with the onset of unhealthy life than with survival after disease suggesting that declines in robustness and resilience with age may have overlapping as well as distinct mechanisms. We conclude that multiple deviations of physiological markers from their normal states (reflected in higher PD) may contribute to increased vulnerability to many diseases and precede their clinical manifestation. This supports potential use of PD in health care as a preclinical indicator of transition from healthy to unhealthy state.

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Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

March 2019

Volume

74

Issue

4

Start / End Page

462 / 468

Related Subject Headings

  • United States
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Health Status
  • Gerontology
  • Female
  • Biomarkers
 

Citation

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Arbeev, K. G., Ukraintseva, S. V., Bagley, O., Zhbannikov, I. Y., Cohen, A. A., Kulminski, A. M., & Yashin, A. I. (2019). "Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 74(4), 462–468. https://doi.org/10.1093/gerona/gly136
Arbeev, Konstantin G., Svetlana V. Ukraintseva, Olivia Bagley, Ilya Y. Zhbannikov, Alan A. Cohen, Alexander M. Kulminski, and Anatoliy I. Yashin. “"Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 74, no. 4 (March 2019): 462–68. https://doi.org/10.1093/gerona/gly136.
Arbeev KG, Ukraintseva SV, Bagley O, Zhbannikov IY, Cohen AA, Kulminski AM, et al. "Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease. The journals of gerontology Series A, Biological sciences and medical sciences. 2019 Mar;74(4):462–8.
Arbeev, Konstantin G., et al. “"Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 74, no. 4, Mar. 2019, pp. 462–68. Epmc, doi:10.1093/gerona/gly136.
Arbeev KG, Ukraintseva SV, Bagley O, Zhbannikov IY, Cohen AA, Kulminski AM, Yashin AI. "Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease. The journals of gerontology Series A, Biological sciences and medical sciences. 2019 Mar;74(4):462–468.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

March 2019

Volume

74

Issue

4

Start / End Page

462 / 468

Related Subject Headings

  • United States
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Health Status
  • Gerontology
  • Female
  • Biomarkers