Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.

Journal Article (Journal Article)

This study assessed genetic contributions to six cognitive domains, identified by the MATRICS Cognitive Consensus Battery as relevant for schizophrenia, cognition-enhancing, clinical trials. Psychiatric Genomics Consortium Schizophrenia polygenic risk scores showed significant negative correlations with each cognitive domain. Genome-wide association analyses identified loci associated with attention/vigilance (rs830786 within HNF4G), verbal memory (rs67017972 near NDUFS4), and reasoning/problem solving (rs76872642 within HDAC9). Gene set analysis identified unique and shared genes across cognitive domains. These findings suggest involvement of common and unique mechanisms across cognitive domains and may contribute to the discovery of new therapeutic targets to treat cognitive deficits in schizophrenia.

Full Text

Duke Authors

Cited Authors

  • Nakahara, S; Medland, S; Turner, JA; Calhoun, VD; Lim, KO; Mueller, BA; Bustillo, JR; O'Leary, DS; Vaidya, JG; McEwen, S; Voyvodic, J; Belger, A; Mathalon, DH; Ford, JM; Guffanti, G; Macciardi, F; Potkin, SG; van Erp, TGM

Published Date

  • November 2018

Published In

Volume / Issue

  • 201 /

Start / End Page

  • 393 - 399

PubMed ID

  • 29907492

Pubmed Central ID

  • PMC6252137

Electronic International Standard Serial Number (EISSN)

  • 1573-2509

Digital Object Identifier (DOI)

  • 10.1016/j.schres.2018.05.041


  • eng

Conference Location

  • Netherlands