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Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.

Publication ,  Journal Article
Nakahara, S; Medland, S; Turner, JA; Calhoun, VD; Lim, KO; Mueller, BA; Bustillo, JR; O'Leary, DS; Vaidya, JG; McEwen, S; Voyvodic, J ...
Published in: Schizophr Res
November 2018

This study assessed genetic contributions to six cognitive domains, identified by the MATRICS Cognitive Consensus Battery as relevant for schizophrenia, cognition-enhancing, clinical trials. Psychiatric Genomics Consortium Schizophrenia polygenic risk scores showed significant negative correlations with each cognitive domain. Genome-wide association analyses identified loci associated with attention/vigilance (rs830786 within HNF4G), verbal memory (rs67017972 near NDUFS4), and reasoning/problem solving (rs76872642 within HDAC9). Gene set analysis identified unique and shared genes across cognitive domains. These findings suggest involvement of common and unique mechanisms across cognitive domains and may contribute to the discovery of new therapeutic targets to treat cognitive deficits in schizophrenia.

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Published In

Schizophr Res

DOI

EISSN

1573-2509

Publication Date

November 2018

Volume

201

Start / End Page

393 / 399

Location

Netherlands

Related Subject Headings

  • Schizophrenic Psychology
  • Schizophrenia
  • Psychiatry
  • Multifactorial Inheritance
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Genetic Loci
  • Female
 

Citation

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Chicago
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Nakahara, S., Medland, S., Turner, J. A., Calhoun, V. D., Lim, K. O., Mueller, B. A., … van Erp, T. G. M. (2018). Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. Schizophr Res, 201, 393–399. https://doi.org/10.1016/j.schres.2018.05.041
Nakahara, Soichiro, Sarah Medland, Jessica A. Turner, Vince D. Calhoun, Kelvin O. Lim, Bryon A. Mueller, Juan R. Bustillo, et al. “Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.Schizophr Res 201 (November 2018): 393–99. https://doi.org/10.1016/j.schres.2018.05.041.
Nakahara S, Medland S, Turner JA, Calhoun VD, Lim KO, Mueller BA, et al. Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. Schizophr Res. 2018 Nov;201:393–9.
Nakahara, Soichiro, et al. “Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.Schizophr Res, vol. 201, Nov. 2018, pp. 393–99. Pubmed, doi:10.1016/j.schres.2018.05.041.
Nakahara S, Medland S, Turner JA, Calhoun VD, Lim KO, Mueller BA, Bustillo JR, O’Leary DS, Vaidya JG, McEwen S, Voyvodic J, Belger A, Mathalon DH, Ford JM, Guffanti G, Macciardi F, Potkin SG, van Erp TGM. Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. Schizophr Res. 2018 Nov;201:393–399.
Journal cover image

Published In

Schizophr Res

DOI

EISSN

1573-2509

Publication Date

November 2018

Volume

201

Start / End Page

393 / 399

Location

Netherlands

Related Subject Headings

  • Schizophrenic Psychology
  • Schizophrenia
  • Psychiatry
  • Multifactorial Inheritance
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Genetic Loci
  • Female