Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling.

Journal Article (Journal Article;Review)

During mammalian brain development, radial glial progenitors balance between proliferation and differentiation to generate the laminated cortical layers in a temporally precise fashion. Defects in the individual steps going into this complex organogenesis can result in cortical malformations and human nervous system disorders. In this issue of Genes & Development, Liu and colleagues (pp. 763-780) present experimental evidence that an evolutionarily conserved cellular polarity gene, Pard3 (partitioning-defective 3), controls the balance of radial glial proliferation and differentiation through interaction with the Hippo signal transduction pathway. Conditional deletion of Pard3 in the developing rodent cortex resulted in striking subcortical band heterotopia, reminiscent of a severe form of human cortical malformation.

Full Text

Duke Authors

Cited Authors

  • Abdi, K; Kuo, CT

Published Date

  • June 1, 2018

Published In

Volume / Issue

  • 32 / 11-12

Start / End Page

  • 740 - 741

PubMed ID

  • 29921662

Pubmed Central ID

  • PMC6049518

Electronic International Standard Serial Number (EISSN)

  • 1549-5477

Digital Object Identifier (DOI)

  • 10.1101/gad.316711.118


  • eng

Conference Location

  • United States