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Computational motility models of neurogastroenterology and neuromodulation.

Publication ,  Journal Article
Barth, BB; Shen, X
Published in: Brain Res
August 15, 2018

The success of neuromodulation therapies, particularly in the brain, spinal cord, and peripheral nerves, has been greatly aided by computational, biophysical models. However, treating gastrointestinal disorders with electrical stimulation has been much less explored, partly because the mode of action of such treatments is unclear, and selection of stimulation parameters is often empirical. Progress in gut neuromodulation is limited by the comparative lack of biophysical models capable of simulating neuromodulation of gastrointestinal function. Here, we review the recently developed biophysical models of electrically-active cells in the gastrointestinal system that contribute to motility. Biophysical models are replacing phenomenologically-defined models due to advancements in electrophysiological characterization of key players in the gut: enteric neurons, smooth muscle fibers, and interstitial cells of Cajal. In this review, we explore existing biophysically-defined cellular and network models that contribute to gastrointestinal motility. We focus on recent models that are laying the groundwork for modeling electrical stimulation of the gastrointestinal system. Developing models of gut neuromodulation will improve our mechanistic understanding of these treatments, leading to better parameterization, selectivity, and efficacy of neuromodulation to treat gastrointestinal disorders. Such models may have direct clinical translation to current neuromodulation therapies, such as sacral nerve stimulation.

Duke Scholars

Published In

Brain Res

DOI

EISSN

1872-6240

Publication Date

August 15, 2018

Volume

1693

Issue

Pt B

Start / End Page

174 / 179

Location

Netherlands

Related Subject Headings

  • Neurotransmitter Agents
  • Neurology & Neurosurgery
  • Humans
  • Gastrointestinal Motility
  • Enteric Nervous System
  • Electric Stimulation
  • Computer Simulation
  • Biophysical Phenomena
  • Animals
  • 5202 Biological psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Barth, B. B., & Shen, X. (2018). Computational motility models of neurogastroenterology and neuromodulation. Brain Res, 1693(Pt B), 174–179. https://doi.org/10.1016/j.brainres.2018.02.038
Barth, Bradley B., and Xiling Shen. “Computational motility models of neurogastroenterology and neuromodulation.Brain Res 1693, no. Pt B (August 15, 2018): 174–79. https://doi.org/10.1016/j.brainres.2018.02.038.
Barth BB, Shen X. Computational motility models of neurogastroenterology and neuromodulation. Brain Res. 2018 Aug 15;1693(Pt B):174–9.
Barth, Bradley B., and Xiling Shen. “Computational motility models of neurogastroenterology and neuromodulation.Brain Res, vol. 1693, no. Pt B, Aug. 2018, pp. 174–79. Pubmed, doi:10.1016/j.brainres.2018.02.038.
Barth BB, Shen X. Computational motility models of neurogastroenterology and neuromodulation. Brain Res. 2018 Aug 15;1693(Pt B):174–179.
Journal cover image

Published In

Brain Res

DOI

EISSN

1872-6240

Publication Date

August 15, 2018

Volume

1693

Issue

Pt B

Start / End Page

174 / 179

Location

Netherlands

Related Subject Headings

  • Neurotransmitter Agents
  • Neurology & Neurosurgery
  • Humans
  • Gastrointestinal Motility
  • Enteric Nervous System
  • Electric Stimulation
  • Computer Simulation
  • Biophysical Phenomena
  • Animals
  • 5202 Biological psychology