ENIGMA military brain injury: A coordinated meta-analysis of diffusion MRI from multiple cohorts


Conference Paper

© 2018 IEEE. Traumatic brain injury (TBI) is a significant cause of morbidity in military Veterans and Service Members. While most individuals recover fully from mild injuries within weeks, some continue to experience symptoms including headaches, disrupted sleep, and other cognitive, behavioral or physical symptoms. Diffusion magnetic resonance imaging (dMRI) shows promise in identifying areas of structural disruption and predicting outcomes. Although some studies suggest widespread structural disruption after brain injury, dMRI studies of military brain injury have yielded mixed results so far, perhaps due to the subtlety of mild injury, individual differences in injury location, severity and mechanism, and co-morbidity with other disorders such as post-traumatic stress disorder (PTSD), depression, and substance abuse. We present preliminary dMRI results from the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) military brain injury working group. We found higher fractional anisotropy (FA) in participants with a history of TBI. Understanding the injury and recovery process, along with factors that influence these, will lead to improved diagnosis and treatment.

Full Text

Duke Authors

Cited Authors

  • Dennis, EL; Wilde, EA; Newsome, MR; Scheibel, RS; Troyanskaya, M; Velez, C; Wade, BSC; Drennon, AM; York, GE; Bigler, ED; Abildskov, TJ; Taylor, BA; Jaramillo, CA; Eapen, B; Belanger, H; Gupta, V; Morey, R; Haswell, C; Levin, HS; Hinds, SR; Walker, WC; Thompson, PM; Tate, DF

Published Date

  • May 23, 2018

Published In

Volume / Issue

  • 2018-April /

Start / End Page

  • 1386 - 1389

Electronic International Standard Serial Number (EISSN)

  • 1945-8452

International Standard Serial Number (ISSN)

  • 1945-7928

International Standard Book Number 13 (ISBN-13)

  • 9781538636367

Digital Object Identifier (DOI)

  • 10.1109/ISBI.2018.8363830

Citation Source

  • Scopus