T regulator and Th17 lymphocytes: Physiological and pathological functions


Journal Article

Over two decades ago, CD4+ T cells were classified into various T cell subsets. Each subset is characterised by its specific cytokine pattern and effector functions in the immune response. This classification has long been confined to two subsets of helper T cells called Th1 and Th2 cells. Recently, new CD4+ T cell populations have been describe, including natural and inducible regulatory T cells and the proinflammatory Th17 cells. The discovery of these new populations provided a better understanding of the pathophysiology of various diseases, including chronic inflammatory disorders including some of autoimmune diseases, cancers and chronic infections. In this review, the generation of regulatory T cells and Th17 cells, the mechanisms used by these T cells to maintain the physiological balance between inflammatory and immunosuppressive immune responses, and their implication in physiopathology of various diseases will be discussed. © 2010 - Elsevier Masson SAS - Tous droits réservés.

Full Text

Duke Authors

Cited Authors

  • Corvaisier-Chiron, M; Beauvillain, C; Hughes, J; Jefferson, A; Raynaud De Mauverger, E; Fernandez, G; Lowy, I; Molrine, D; Vingert, B; Perez-Patrigeon, S; Jeannin, P; Bourne, Y; Radic, Z; Aráoz, R; Weeks, A; Alia, G; Clarke, R; Peden, J; Steidl, C; Lee, T; Shah, S; Liang, S; Wang, H; Newell, K; Asare, A; Kirk, A; Studebaker, A; Kreofsky, C; Pierson, C; Lam, C; Yoo, T; Hiner, B

Published Date

  • January 1, 2010

Published In

Volume / Issue

  • 2010 / 424

Start / End Page

  • 31 - 40

International Standard Serial Number (ISSN)

  • 1773-035X

Digital Object Identifier (DOI)

  • 10.1016/s1773-035x(10)70607-9

Citation Source

  • Scopus