Translational bioinformatics in mental health: open access data sources and computational biomarker discovery.

Journal Article (Journal Article;Review)

Mental illness is increasingly recognized as both a significant cost to society and a significant area of opportunity for biological breakthrough. As -omics and imaging technologies enable researchers to probe molecular and physiological underpinnings of multiple diseases, opportunities arise to explore the biological basis for behavioral health and disease. From individual investigators to large international consortia, researchers have generated rich data sets in the area of mental health, including genomic, transcriptomic, metabolomic, proteomic, clinical and imaging resources. General data repositories such as the Gene Expression Omnibus (GEO) and Database of Genotypes and Phenotypes (dbGaP) and mental health (MH)-specific initiatives, such as the Psychiatric Genomics Consortium, MH Research Network and PsychENCODE represent a wealth of information yet to be gleaned. At the same time, novel approaches to integrate and analyze data sets are enabling important discoveries in the area of mental and behavioral health. This review will discuss and catalog into an organizing framework the increasingly diverse set of MH data resources available, using schizophrenia as a focus area, and will describe novel and integrative approaches to molecular biomarker discovery that make use of mental health data.

Full Text

Duke Authors

Cited Authors

  • Tenenbaum, JD; Bhuvaneshwar, K; Gagliardi, JP; Fultz Hollis, K; Jia, P; Ma, L; Nagarajan, R; Rakesh, G; Subbian, V; Visweswaran, S; Zhao, Z; Rozenblit, L

Published Date

  • May 21, 2019

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 842 - 856

PubMed ID

  • 29186302

Pubmed Central ID

  • PMC6585382

Electronic International Standard Serial Number (EISSN)

  • 1477-4054

Digital Object Identifier (DOI)

  • 10.1093/bib/bbx157


  • eng

Conference Location

  • England