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Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure.

Publication ,  Journal Article
Versporten, A; Gyssens, IC; Pulcini, C; Monnier, AA; Schouten, J; Milanic, R; Stanic Benic, M; Tebano, G; Le Maréchal, M; Zanichelli, V ...
Published in: J Antimicrob Chemother
June 1, 2018

BACKGROUND: The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of 'responsible' antibiotic use. OBJECTIVES: To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. METHODS: First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. RESULTS: A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. CONCLUSIONS: A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter)national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use.

Duke Scholars

Published In

J Antimicrob Chemother

DOI

EISSN

1460-2091

Publication Date

June 1, 2018

Volume

73

Issue

suppl_6

Start / End Page

vi59 / vi66

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Quality Indicators, Health Care
  • Outpatients
  • Microbiology
  • Internationality
  • Humans
  • Global Health
  • Endpoint Determination
  • Delphi Technique
  • Delivery of Health Care
 

Citation

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Versporten, A., Gyssens, I. C., Pulcini, C., Monnier, A. A., Schouten, J., Milanic, R., … DRIVE-AB WP1 group, . (2018). Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure. J Antimicrob Chemother, 73(suppl_6), vi59–vi66. https://doi.org/10.1093/jac/dky119
Versporten, Ann, Inge C. Gyssens, Céline Pulcini, Annelie A. Monnier, Jeroen Schouten, Romina Milanic, Mirjana Stanic Benic, et al. “Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure.J Antimicrob Chemother 73, no. suppl_6 (June 1, 2018): vi59–66. https://doi.org/10.1093/jac/dky119.
Versporten A, Gyssens IC, Pulcini C, Monnier AA, Schouten J, Milanic R, et al. Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure. J Antimicrob Chemother. 2018 Jun 1;73(suppl_6):vi59–66.
Versporten, Ann, et al. “Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure.J Antimicrob Chemother, vol. 73, no. suppl_6, June 2018, pp. vi59–66. Pubmed, doi:10.1093/jac/dky119.
Versporten A, Gyssens IC, Pulcini C, Monnier AA, Schouten J, Milanic R, Stanic Benic M, Tebano G, Le Maréchal M, Zanichelli V, Huttner B, Vlahovic-Palcevski V, Goossens H, Hulscher ME, Adriaenssens N, DRIVE-AB WP1 group. Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure. J Antimicrob Chemother. 2018 Jun 1;73(suppl_6):vi59–vi66.
Journal cover image

Published In

J Antimicrob Chemother

DOI

EISSN

1460-2091

Publication Date

June 1, 2018

Volume

73

Issue

suppl_6

Start / End Page

vi59 / vi66

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Quality Indicators, Health Care
  • Outpatients
  • Microbiology
  • Internationality
  • Humans
  • Global Health
  • Endpoint Determination
  • Delphi Technique
  • Delivery of Health Care