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RECONSTITUTION OF THE ELLIPSOID ZONE WITH TOCILIZUMAB IN AUTOIMMUNE RETINOPATHY.

Publication ,  Journal Article
Finn, AP; Keenan, RT; Jaffe, GJ
Published in: Retin Cases Brief Rep
2020

PURPOSE: To demonstrate improvement and stabilization of retinal findings, including recalcitrant cystoid macular edema, in a patient with nonparaneoplastic autoimmune retinopathy after treatment with tocilizumab, a humanized monoclonal antibody against soluble and membrane-bound IL-6 receptor. METHODS: Observational case report. A 46-year-old woman was diagnosed with nonparaneoplastic autoimmune retinopathy and followed over 4 years on various immunosuppressive medications with worsening disease and recalcitrant cystoid macular edema. This report describes the rapid improvement and stabilization of her ocular disease once tocilizumab was initiated. RESULTS: Tocilizumab, a monoclonal antibody against the IL-6 receptor, was initiated at a dose of 8 mg/kg every 4 weeks. Cystoid macular edema was significantly decreased after just two infusions and nearly resolved after five infusions. Ellipsoid zone and outer retinal integrity also improved on optical coherence tomography. The patient tolerated the medication with limited side effects. CONCLUSION: Long-term immunosuppression is the cornerstone of treatment for nonparaneoplastic autoimmune retinopathy, although success is highly variable. We report a case treated with tocilizumab with dramatic improvement in refractory macular edema and reconstitution of the ellipsoid zone on optical coherence tomography in a patient with nonparaneoplastic autoimmune retinopathy. This case highlights the potential role of treatment with an IL-6 inhibitor in autoimmune retinopathy though further studies are needed.

Duke Scholars

Published In

Retin Cases Brief Rep

DOI

EISSN

1937-1578

Publication Date

2020

Volume

14

Issue

4

Start / End Page

297 / 300

Location

United States

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Retinal Diseases
  • Receptors, Interleukin-6
  • Middle Aged
  • Macular Edema
  • Humans
  • Fluorescein Angiography
  • Female
  • Autoimmune Diseases
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Finn, A. P., Keenan, R. T., & Jaffe, G. J. (2020). RECONSTITUTION OF THE ELLIPSOID ZONE WITH TOCILIZUMAB IN AUTOIMMUNE RETINOPATHY. Retin Cases Brief Rep, 14(4), 297–300. https://doi.org/10.1097/ICB.0000000000000766
Finn, Avni P., Robert T. Keenan, and Glenn J. Jaffe. “RECONSTITUTION OF THE ELLIPSOID ZONE WITH TOCILIZUMAB IN AUTOIMMUNE RETINOPATHY.Retin Cases Brief Rep 14, no. 4 (2020): 297–300. https://doi.org/10.1097/ICB.0000000000000766.
Finn AP, Keenan RT, Jaffe GJ. RECONSTITUTION OF THE ELLIPSOID ZONE WITH TOCILIZUMAB IN AUTOIMMUNE RETINOPATHY. Retin Cases Brief Rep. 2020;14(4):297–300.
Finn, Avni P., et al. “RECONSTITUTION OF THE ELLIPSOID ZONE WITH TOCILIZUMAB IN AUTOIMMUNE RETINOPATHY.Retin Cases Brief Rep, vol. 14, no. 4, 2020, pp. 297–300. Pubmed, doi:10.1097/ICB.0000000000000766.
Finn AP, Keenan RT, Jaffe GJ. RECONSTITUTION OF THE ELLIPSOID ZONE WITH TOCILIZUMAB IN AUTOIMMUNE RETINOPATHY. Retin Cases Brief Rep. 2020;14(4):297–300.

Published In

Retin Cases Brief Rep

DOI

EISSN

1937-1578

Publication Date

2020

Volume

14

Issue

4

Start / End Page

297 / 300

Location

United States

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Retinal Diseases
  • Receptors, Interleukin-6
  • Middle Aged
  • Macular Edema
  • Humans
  • Fluorescein Angiography
  • Female
  • Autoimmune Diseases