Outcomes of patients with a pretransplant history of early-stage melanoma.


Journal Article

A history of melanoma within the preceding 5 years is commonly considered a contraindication to solid organ transplantation. We investigated how a pretransplant history of melanoma impacts patient survival and melanoma recurrence. Institutional Review Board approval was obtained, and Duke's retrospective database was used to identify 4552 patients who underwent a solid organ transplant at Duke University from 1 January 2001 to 31 December 2016. Data with regard to the transplant, melanoma characteristics, rejection episodes, and survival were recorded. Of 4552 patients who underwent a solid organ transplant, 12 (0.3%) had a history of melanoma before transplant (six with melanoma in situ and six with stage I disease). The median time between melanoma diagnosis and transplant was 4.13 years (range: 1.1-13.3 years). The study cohort consisted of four liver transplants, four lung transplants, one kidney transplant, one heart transplant, one small bowel transplant, and one multivisceral transplant. At the median follow-up time of 2.8 years, 10 (83.3%) patients were alive. In nonmelanoma cohorts, the 3-year survival is 70% for thoracic transplants, 78% for liver transplants, and 88% for kidney transplants. In well-selected patients with a history of early-stage melanoma and an appropriate time interval between melanoma treatment and transplant, post-transplant outcomes are favorable.

Full Text

Duke Authors

Cited Authors

  • Puza, CJ; Barbas, AS; Mosca, PJ

Published Date

  • October 2018

Published In

Volume / Issue

  • 28 / 5

Start / End Page

  • 471 - 474

PubMed ID

  • 29944608

Pubmed Central ID

  • 29944608

Electronic International Standard Serial Number (EISSN)

  • 1473-5636

Digital Object Identifier (DOI)

  • 10.1097/CMR.0000000000000471


  • eng

Conference Location

  • England