The epicardium as a hub for heart regeneration.

Journal Article (Journal Article;Review)

After decades of directed research, no effective regenerative therapy is currently available to repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops the heart in all vertebrates, has emerged as a new player in cardiac repair and regeneration. The epicardium is essential for muscle regeneration in the zebrafish model of innate heart regeneration, and the epicardium also participates in fibrotic responses in mammalian hearts. This structure serves as a source of crucial cells, such as vascular smooth muscle cells, pericytes, and fibroblasts, during heart development and repair. The epicardium also secretes factors that are essential for proliferation and survival of cardiomyocytes. In this Review, we describe recent advances in our understanding of the biology of the epicardium and the effect of these findings on the candidacy of this structure as a therapeutic target for heart repair and regeneration.

Full Text

Duke Authors

Cited Authors

  • Cao, J; Poss, KD

Published Date

  • October 2018

Published In

Volume / Issue

  • 15 / 10

Start / End Page

  • 631 - 647

PubMed ID

  • 29950578

Pubmed Central ID

  • PMC6143401

Electronic International Standard Serial Number (EISSN)

  • 1759-5010

Digital Object Identifier (DOI)

  • 10.1038/s41569-018-0046-4


  • eng

Conference Location

  • England