Induction and Characterization of the Allergic Eye Disease Mouse Model.

Journal Article (Journal Article)

Ocular IgE-associated allergy ranges from mild disease (seasonal and perennial allergic conjunctivitis) to more chronic/severe and vision-threatening forms (atopic and vernal keratoconjunctivitis). Whereas mild forms of disease have been studied extensively, less is known about the more chronic forms. Our lab has helped to address this knowledge gap by developing and characterizing an allergen-induced, chronic/severe, IgE-associated model of ocular allergy referred to as the severe allergic eye disease (AED) model. It is distinct from previously described models that mimic the more mild forms, referred to in the literature as the allergic conjunctivitis (AC) model. The purpose of this method article is to detail the protocol to induce and characterize the AED model and directly compare these mice to the mild AC model. Troubleshooting and implications are also discussed.

Full Text

Duke Authors

Cited Authors

  • Reyes, NJ; Mathew, R; Saban, DR

Published Date

  • 2018

Published In

Volume / Issue

  • 1799 /

Start / End Page

  • 49 - 57

PubMed ID

  • 29956143

Electronic International Standard Serial Number (EISSN)

  • 1940-6029

Digital Object Identifier (DOI)

  • 10.1007/978-1-4939-7896-0_5


  • eng

Conference Location

  • United States