Skip to main content
Journal cover image

Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation.

Publication ,  Journal Article
Sullivan, KM; Majhail, NS; Bredeson, C; Carpenter, PA; Chatterjee, S; Crofford, LJ; Georges, GE; Nash, RA; Pasquini, MC; Sarantopoulos, S ...
Published in: Biol Blood Marrow Transplant
October 2018

Systemic sclerosis is a progressive inflammatory disease that is frequently fatal and has limited treatment options. High-dose chemotherapy with autologous hematopoietic cell transplantation (AHCT) has been evaluated as treatment for this disease in observational studies, multicenter randomized controlled clinical trials, and meta-analyses. On behalf of the American Society for Blood and Marrow Transplantation (ASBMT), a panel of experts in transplantation and rheumatology was convened to review available evidence and make a recommendation on AHCT as an indication for systemic sclerosis. Three randomized trials have compared the efficacy of AHCT with cyclophosphamide only, and all demonstrated benefit for the AHCT arm for their primary endpoint (improvement in the American Scleroderma Stem Cell versus Immune Suppression Trial, event-free survival in Autologous Stem Cell Transplantation International Scleroderma trial, and change in global rank composite score in Scleroderma: Cyclophosphamide or Transplantation trial). AHCT recipients also had better overall survival and a lower rate of disease progression. These findings have been confirmed in subsequent meta-analyses. Based on this high-quality evidence, the ASBMT recommends systemic sclerosis should be considered as a "standard of care" indication for AHCT. Close collaboration between rheumatologists and transplant clinicians is critical for optimizing patient selection and patient outcomes. Transplant centers in the United States are strongly encouraged to report patient and outcomes data to the Center for International Blood and Marrow Transplant Research on their patients receiving AHCT for this indication.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

October 2018

Volume

24

Issue

10

Start / End Page

1961 / 1964

Location

United States

Related Subject Headings

  • United States
  • Societies, Medical
  • Scleroderma, Systemic
  • Randomized Controlled Trials as Topic
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Cyclophosphamide
  • Bone Marrow Transplantation
  • Autografts
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sullivan, K. M., Majhail, N. S., Bredeson, C., Carpenter, P. A., Chatterjee, S., Crofford, L. J., … St Clair, E. W. (2018). Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant, 24(10), 1961–1964. https://doi.org/10.1016/j.bbmt.2018.06.025
Sullivan, Keith M., Navneet S. Majhail, Christopher Bredeson, Paul A. Carpenter, Soumya Chatterjee, Leslie J. Crofford, George E. Georges, et al. “Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant 24, no. 10 (October 2018): 1961–64. https://doi.org/10.1016/j.bbmt.2018.06.025.
Sullivan KM, Majhail NS, Bredeson C, Carpenter PA, Chatterjee S, Crofford LJ, et al. Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2018 Oct;24(10):1961–4.
Sullivan, Keith M., et al. “Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant, vol. 24, no. 10, Oct. 2018, pp. 1961–64. Pubmed, doi:10.1016/j.bbmt.2018.06.025.
Sullivan KM, Majhail NS, Bredeson C, Carpenter PA, Chatterjee S, Crofford LJ, Georges GE, Nash RA, Pasquini MC, Sarantopoulos S, Storek J, Savani B, St Clair EW. Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2018 Oct;24(10):1961–1964.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

October 2018

Volume

24

Issue

10

Start / End Page

1961 / 1964

Location

United States

Related Subject Headings

  • United States
  • Societies, Medical
  • Scleroderma, Systemic
  • Randomized Controlled Trials as Topic
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Cyclophosphamide
  • Bone Marrow Transplantation
  • Autografts