CHARACTERIZATION OF THE CHOROIDAL VASCULATURE IN MYOPIC MACULOPATHY WITH OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY.
Journal Article
Purpose
To characterize the choriocapillaris (CC) in highly myopic eyes with myopic maculopathy, using optical coherence tomographic angiography.Methods
Prospective, clinic-based study of 42 eyes of 38 patients with high myopia (≤-6 diopters and axial length ≥26.5 mm). Myopic maculopathy was graded from fundus photographs according to the Meta-Analysis for Pathologic Myopia classification. Macular 3 × 3 mm en face optical coherence tomographic angiographic images were obtained with swept-source optical coherence tomographic angiography and graded for CC flow impairment as follows: 1) intact CC, 2) focal (<1 mm), and 3) extensive (>1 mm).Results
Of the 42 eyes, 17 (39.5%) had tessellated fundus, 20 (46.5%) had diffuse, and 6 (14.0%) had patchy atrophy. Choriocapillaris flow impairment was observed in all eyes with diffuse and patchy atrophy. Even in eyes with tessellated fundus only, CC signal voids were seen in 3 eyes (17.6%). With increasingly severe myopic maculopathy, the pattern of CC flow impairment changed from predominantly focal to predominantly extensive.Conclusion
Choriocapillaris flow impairment was observed in many highly myopic eyes, even in those with mild fundus changes, and worsened with increasing severity of myopic maculopathy. Longitudinal studies are needed to assess whether CC flow impairment predicts the risk of myopic maculopathy progression.Full Text
Duke Authors
Cited Authors
- Wong, CW; Teo, YCK; Tsai, STA; Ting, SWD; Yeo, YSI; Wong, WKD; Lee, SY; Wong, TY; Cheung, CMG
Published Date
- September 2019
Published In
Volume / Issue
- 39 / 9
Start / End Page
- 1742 - 1750
PubMed ID
- 29952919
Pubmed Central ID
- 29952919
Electronic International Standard Serial Number (EISSN)
- 1539-2864
International Standard Serial Number (ISSN)
- 0275-004X
Digital Object Identifier (DOI)
- 10.1097/iae.0000000000002233
Language
- eng