Phenotypic features of central sensitization


Journal Article

© 2018 Wiley Periodicals, Inc. The current manuscript reviews approaches for phenotyping central sensitization (CS). The manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S.P.A.C.E.). Each of the assessment domains are described with reference to CS and their presence in chronic overlapping pain conditions (COPCs)—conditions likely influenced by CS. Chronic overlapping pain conditions likely represent clinical diagnostic phenotypes of CS. Components of CS can also be assessed using QST or self-report instruments designed to assess single elements of CS or more general composite indices.

Full Text

Cited Authors

  • Williams, DA

Published Date

  • June 1, 2018

Published In

Volume / Issue

  • 23 / 2

Electronic International Standard Serial Number (EISSN)

  • 1751-9861

International Standard Serial Number (ISSN)

  • 1071-2089

Digital Object Identifier (DOI)

  • 10.1111/jabr.12135

Citation Source

  • Scopus