Fate of patients with newly diagnosed acute myeloid leukemia who fail primary induction therapy.


Journal Article

The aim of this study was to describe the fate of patients with newly diagnosed acute myeloid leukemia (AML) who did not achieve an initial remission while being treated on a contemporary cooperative group trial. We analyzed the outcome of patients entered into S0106, a recently reported cooperative group trial for patients with newly diagnosed AML. A total of 589 eligible patients was treated, of whom 150 (25%) did not achieve a remission while on study and were available for further analysis. The 4-year survival rate for the entire cohort of 150 patients was 23%. Among the 64 patients who received an allogeneic hematopoietic cell transplant, the 4-year survival rate was 48% compared with 4% for the 86 patients who did not undergo transplantation. Among those transplanted, we could not detect a difference in outcome according to remission status, donor source, type of preparative regimen, or cytogenetic risk category. More than 20% of patients with newly diagnosed AML who fail induction therapy can still be cured, particularly if they are able to receive an allogeneic hematopoietic cell transplant. These results suggest that early HLA typing and donor identification are important components of the initial therapy of AML.

Full Text

Duke Authors

Cited Authors

  • Othus, M; Appelbaum, FR; Petersdorf, SH; Kopecky, KJ; Slovak, M; Nevill, T; Brandwein, J; Larson, RA; Stiff, PJ; Walter, RB; Tallman, MS; Stenke, L; Erba, HP

Published Date

  • March 2015

Published In

Volume / Issue

  • 21 / 3

Start / End Page

  • 559 - 564

PubMed ID

  • 25536215

Pubmed Central ID

  • 25536215

Electronic International Standard Serial Number (EISSN)

  • 1523-6536

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2014.10.025


  • eng

Conference Location

  • United States