Outpatient consolidation treatment with clofarabine in a phase 2 study of older adult patients with previously untreated acute myelogenous leukemia.

Journal Article (Journal Article)

This report describes outpatient (OP) administration of clofarabine in older patients (≥60 years) with untreated acute myelogenous leukemia (AML). Overall, 112 patients underwent clofarabine induction. Clofarabine was administered to 35 OPs for a total of 72 OP cycles, with 81% of these cycles representing consolidation treatment. Median length of hospital stay was 0-6 days and 5-25 days across OP and inpatient (IP) cycles, respectively. The most common adverse events (AEs) were nausea, vomiting, diarrhea, febrile neutropenia, edema, hypokalemia and pneumonia. The overall frequency of treatment-emergent grade ≥3 AEs and serious AEs was generally not different with IP or OP administration of clofarabine. No deaths were reported within 30 days following OP or IP consolidation cycles. In the appropriately selected older patient, OP administration of clofarabine consolidation appears feasible, is as well tolerated as IP administration and has potential to contribute to the quality of life in elderly patients with AML.

Full Text

Duke Authors

Cited Authors

  • Claxton, D; Erba, HP; Faderl, S; Arellano, M; Lyons, RM; Kovacsovics, T; Gabrilove, J; Huebner, D; Gandhi, PJ; Kantarjian, H; CLASSIC II Investigators,

Published Date

  • March 2012

Published In

Volume / Issue

  • 53 / 3

Start / End Page

  • 435 - 440

PubMed ID

  • 21877883

Pubmed Central ID

  • 21877883

Electronic International Standard Serial Number (EISSN)

  • 1029-2403

Digital Object Identifier (DOI)

  • 10.3109/10428194.2011.616960


  • eng

Conference Location

  • United States