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Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.

Publication ,  Journal Article
Tran, EEH; Simmons, JA; Bartesaghi, A; Shoemaker, CJ; Nelson, E; White, JM; Subramaniam, S
Published in: Journal of virology
September 2014

The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function.

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Published In

Journal of virology

DOI

EISSN

1098-5514

ISSN

0022-538X

Publication Date

September 2014

Volume

88

Issue

18

Start / End Page

10958 / 10962

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Protein Structure, Tertiary
  • Models, Molecular
  • Humans
  • Hemorrhagic Fever, Ebola
  • Ebolavirus
  • Cryoelectron Microscopy
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Tran, E. E. H., Simmons, J. A., Bartesaghi, A., Shoemaker, C. J., Nelson, E., White, J. M., & Subramaniam, S. (2014). Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography. Journal of Virology, 88(18), 10958–10962. https://doi.org/10.1128/jvi.00870-14
Tran, Erin E. H., James A. Simmons, Alberto Bartesaghi, Charles J. Shoemaker, Elizabeth Nelson, Judith M. White, and Sriram Subramaniam. “Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.Journal of Virology 88, no. 18 (September 2014): 10958–62. https://doi.org/10.1128/jvi.00870-14.
Tran EEH, Simmons JA, Bartesaghi A, Shoemaker CJ, Nelson E, White JM, et al. Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography. Journal of virology. 2014 Sep;88(18):10958–62.
Tran, Erin E. H., et al. “Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.Journal of Virology, vol. 88, no. 18, Sept. 2014, pp. 10958–62. Epmc, doi:10.1128/jvi.00870-14.
Tran EEH, Simmons JA, Bartesaghi A, Shoemaker CJ, Nelson E, White JM, Subramaniam S. Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography. Journal of virology. 2014 Sep;88(18):10958–10962.

Published In

Journal of virology

DOI

EISSN

1098-5514

ISSN

0022-538X

Publication Date

September 2014

Volume

88

Issue

18

Start / End Page

10958 / 10962

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Protein Structure, Tertiary
  • Models, Molecular
  • Humans
  • Hemorrhagic Fever, Ebola
  • Ebolavirus
  • Cryoelectron Microscopy
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences