Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.

Published

Journal Article

The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function.

Full Text

Duke Authors

Cited Authors

  • Tran, EEH; Simmons, JA; Bartesaghi, A; Shoemaker, CJ; Nelson, E; White, JM; Subramaniam, S

Published Date

  • September 2014

Published In

Volume / Issue

  • 88 / 18

Start / End Page

  • 10958 - 10962

PubMed ID

  • 25008940

Pubmed Central ID

  • 25008940

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.00870-14

Language

  • eng