Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.

Published

Journal Article

To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer.Genetic clinics.Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire.None.Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment.There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer.Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.

Full Text

Cited Authors

  • Gronwald, J; Glass, K; Rosen, B; Karlan, B; Tung, N; Neuhausen, SL; Moller, P; Ainsworth, P; Sun, P; Narod, SA; Lubinski, J; Kotsopoulos, J; Hereditary Breast Cancer Clinical Study Group,

Published Date

  • March 2016

Published In

Volume / Issue

  • 105 / 3

Start / End Page

  • 781 - 785

PubMed ID

  • 26698676

Pubmed Central ID

  • 26698676

Electronic International Standard Serial Number (EISSN)

  • 1556-5653

International Standard Serial Number (ISSN)

  • 0015-0282

Digital Object Identifier (DOI)

  • 10.1016/j.fertnstert.2015.11.034

Language

  • eng